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Current Neurology and Neuroscience Reports, 2010
Nocturnal leg cramps are a frequent cause of sleep disturbance among the general population, especially among the elderly. These painful episodes can delay sleep onset and awaken the patient from sleep, as well as delay subsequent return to sleep. Different mechanisms have been proposed to explain this phenomenon.
Thorpy Michael J
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Nocturnal leg cramps are a frequent cause of sleep disturbance among the general population, especially among the elderly. These painful episodes can delay sleep onset and awaken the patient from sleep, as well as delay subsequent return to sleep. Different mechanisms have been proposed to explain this phenomenon.
Thorpy Michael J
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A review of nocturnal leg cramps in older people [PDF]
Age and Ageing, 2016 Nocturnal leg cramps are common and troublesome, especially in later life, and have a significant impact on quality of life, particularly sleep quality. This article reviews the current state of knowledge regarding the diagnosis, frequency, pathophysiology and management of cramps.
Eamon C Mulkerrin +2 more
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Differentiating nocturnal leg cramps and restless legs syndrome
Expert Review of Neurotherapeutics, 2014Leg pain and discomfort are common complaints in any primary physician's clinic. Two common causes of pain or discomfort in legs are nocturnal leg cramps (NLC) and restless leg syndrome (RLS). NLC present as painful and sudden contractions mostly in part of the calf.
Abdul Qayyum Rana, William G Ondo
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Quinine for nocturnal leg cramps [PDF]
Journal of General Internal Medicine, 1998 With respect to the use of quinine for the treatment of nocturnal leg cramps, to determine whether the findings of a previously performed meta-analysis of published data are altered with the addition of unpublished data, and whether publication bias is present in this area.A meta-analysis of eight (four published and four unpublished) randomized ...
Malcolm Man-Son-Hing +2 more
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Simple Cure for Nocturnal Leg Cramps
New England Journal of Medicine, 1979W M Mccormack, G F Grady
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Treatment of nocturnal leg cramps.
Archives of internal medicine, 1994In their placebo-controlled, three-period, crossover trial of quinine vs vitamin E for nocturnal leg cramps, Connolly et al 1 provide interesting data on the efficacy of quinine. 1 However, we believe that, because the study design fails to adequately negate the likelihood of "period," "carryover," or "sequence" effects, 2 one cannot exclude the ...
L L, Brunetti +4 more
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Nocturnal Leg Cramps (Systremma)
Southern Medical Journal, 1974AbstractThe following clinical observations confirm an earlier preliminary report of 26 patients, describing the therapeutic response of nocturnal leg cramps and other types of muscle spasms to adequate doses of d, alphatocopheryl acetate.
S, Ayres, R, Mihan
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Quinine for nocturnal leg cramps?
Drug and Therapeutics Bulletin, 1996When we reviewed the management of nocturnal muscle cramps over 12 years ago,1,2 we concluded that there was little evidence of efficacy for any treatment, but what there was favoured quinine. Here we re-examine the data, including material published since our original article, and assess whether the position has changed.
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