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Treatment of nocturnal leg cramps.
Archives of internal medicine, 1994In their placebo-controlled, three-period, crossover trial of quinine vs vitamin E for nocturnal leg cramps, Connolly et al 1 provide interesting data on the efficacy of quinine. 1 However, we believe that, because the study design fails to adequately negate the likelihood of "period," "carryover," or "sequence" effects, 2 one cannot exclude the ...
L L, Brunetti +4 more
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Nocturnal Leg Cramps (Systremma)
Southern Medical Journal, 1974AbstractThe following clinical observations confirm an earlier preliminary report of 26 patients, describing the therapeutic response of nocturnal leg cramps and other types of muscle spasms to adequate doses of d, alphatocopheryl acetate.
S, Ayres, R, Mihan
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Quinine for nocturnal leg cramps?
Drug and Therapeutics Bulletin, 1996When we reviewed the management of nocturnal muscle cramps over 12 years ago,1,2 we concluded that there was little evidence of efficacy for any treatment, but what there was favoured quinine. Here we re-examine the data, including material published since our original article, and assess whether the position has changed.
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American family physician, 2012
Up to 60 percent of adults report that they have had nocturnal leg cramps. The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Nocturnal leg cramps are
Richard E, Allen, Karl A, Kirby
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Up to 60 percent of adults report that they have had nocturnal leg cramps. The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Nocturnal leg cramps are
Richard E, Allen, Karl A, Kirby
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Spine, 2009
Questionnaire survey on leg cramps for patients with lumbar spinal canal stenosis (LCS).To evaluate the prevalence of leg cramps in patients with LCS treated surgically and the relationship between leg cramps and the surgical outcomes.Although it has been anecdotally reported that LCS patients have suffered from leg cramps, the true prevalence remains ...
Morio, Matsumoto +9 more
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Questionnaire survey on leg cramps for patients with lumbar spinal canal stenosis (LCS).To evaluate the prevalence of leg cramps in patients with LCS treated surgically and the relationship between leg cramps and the surgical outcomes.Although it has been anecdotally reported that LCS patients have suffered from leg cramps, the true prevalence remains ...
Morio, Matsumoto +9 more
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JAMA: The Journal of the American Medical Association, 1980
NOCTURNAL leg muscle cramping (NLMC) is a frequent complaint heard by physicians in all specialties, from patients of all age groups, though probably most commonly in the elderly. Such muscle cramping usually involves the calf muscles (gastrocnemius or soleus) or the small intrinsic muscles of the sole of the foot.
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NOCTURNAL leg muscle cramping (NLMC) is a frequent complaint heard by physicians in all specialties, from patients of all age groups, though probably most commonly in the elderly. Such muscle cramping usually involves the calf muscles (gastrocnemius or soleus) or the small intrinsic muscles of the sole of the foot.
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Treatment of Nocturnal Leg Cramps
Archives of Internal Medicine, 1992Objective.— This study compared the efficacy and safety of quinine sulfate, vitamin E, and placebo in the treatment of nocturnal leg cramps. Design.— A random-order, double-blind, placebocontrolled crossover trial was performed. Setting.— The study was conducted at the Veterans Affairs Medical Center, White River Junction, Vt.
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Treatment of Nocturnal Leg Cramps-Reply
Archives of Internal Medicine, 1994We thank Brunetti and colleagues for their comments. They make some interesting points about the potential biases inherent in crossover trials, but we do not feel that they invalidate the conclusions of our study showing the effectiveness of quinine as a treatment for nocturnal leg cramps. The initial "run-in" period was to ensure some measurable cramp
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[Nocturnal leg cramps--their causes and treatment].
Medizinische Klinik, 1980Organic causes for nocturnal or recumbency leg cramps as venous, arterial, statical, nervous, rheumatical and metabolic diseases such as tetany, diabetes and gout must be excluded. This means also electrolyte disturbances during a medical treatment, for example with diuretics. In addition there is a very high portion of idiopathic cramps.
H, Mörl, H A, Dieterich
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