Results 81 to 90 of about 31,181 (267)

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Inverse nodal problem for a p-Laplacian Sturm-Liouville equation with polynomially boundary condition

Electronic Journal of Differential Equations, 2018
In this article, we extend solution of inverse nodal problem for one-dimensional p-Laplacian equation to the case when the boundary condition is polynomially eigenparameter.
Hikmet Koyunbakan, Tuba Gulsen, Emrah Yilmaz   +2 more
doaj  

Room‐Temperature Magnetic Skyrmions and Intrinsic Anomalous Hall Effect in a Nodal‐Line Kagomé Ferromagnet MnRhP

Advanced Science, EarlyView.
MnRhP has been identified as a novel kagomé magnet that hosts magnetic skyrmions above room temperature and exhibits a large intrinsic anomalous Hall effect. The latter originates from Berry curvature associated with gapped nodal lines, establishing MnRhP as a promising platform for exploring high‐temperature topological phenomena in both real and ...
Kosuke Karube, Ming‐Chun Jiang, Lukas Keller, Jonathan S. White, Yi Ling Chiew, Xiuzhen Yu, Guang Yu Guo, Ryotaro Arita, Yoshinori Tokura, Yasujiro Taguchi   +9 more
wiley   +1 more source

Nodal method for handling irregularly deformed geometries in hexagonal lattice cores

Nuclear Engineering and Technology
The hexagonal nodal code RENUS has been enhanced to handle irregularly deformed hexagonal assemblies. The underlying RENUS methods involving triangle-based polynomial expansion nodal (T-PEN) and corner point balance (CPB) were extended in a way to use ...
Seongchan Kim, Han Gyu Joo, Hyun Chul Lee   +2 more
doaj   +1 more source

A Janus‐Like Bio‐Inspired Strategy for 3D‐Printed Bimetallic Metamaterials with Excellent Thermal‐Protection and Load Bearing Capacity

Advanced Science, EarlyView.
A Janus‐like bio‐inspired strategy is proposed for integrally 3D‐printed bimetallic metamaterials. Inspired by shell bilayers, a heat‐resistant AlSiFeMnNiMg alloy and a SiC‐reinforced AlSi10Mg with different SiC volume fractions are arranged as an architected pair.
Zhicheng Dong, Wei Cheng, Yu He, Ben Jia, Xiaopeng Wan, Heyuan Huang   +5 more
wiley   +1 more source

Survivable Network Design and Optimization with Network Families

Journal of Computer Networks and Communications, 2014
In modeling communication networks for simulation of survivability schemes, one goal is often to implement these schemes across varying degrees of nodal connectivity to get unbiased performance results.
Brody Todd, Abiose Ibigbami, John Doucette   +2 more
doaj   +1 more source

Nodal sets for solutions of elliptic equations

Journal of Differential Geometry, 1989
On etudie, sur un domaine connexe Ω⊂R n , l'ensemble zero u −1 {0} d'une solution u d'une equation elliptique a ij D i D j u+b j D j u+cu=0 ou a ij , b j , c sont bornes et a ij est continu. On demontre que la mesure de Hausdorff a (n−1) dimensions de u − 1 {0} est finie dans un voisinage d'un point x 0 ∈Ω ou u a un ordre fini d ...
Hardt, Robert, Simon, Leon
openaire   +2 more sources