Results 101 to 110 of about 51,241 (256)

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Skin‐draining lymph node priming is sufficient to induce sterile immunity against pre‐erythrocytic malaria

EMBO Molecular Medicine, 2012
The Plasmodium‐infected hepatocyte has been considered necessary to prime the immune responses leading to sterile protection after vaccination with attenuated sporozoites.
Michel Obeid, Jean‐François Franetich, Audrey Lorthiois, Audrey Gego, Anne Charlotte Grüner, Maurel Tefit, Claude Boucheix, Georges Snounou, Dominique Mazier   +8 more
doaj   +1 more source

Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization

Frontiers in Immunology, 2017
Mice transplanted with human cord blood-derived hematopoietic stem cells (HSCs) became a powerful experimental tool for studying the heterogeneity of human immune reconstitution and immune responses in vivo.
Valery Volk, Andreas I. Reppas, Philippe A. Robert, Loukia M. Spineli, Bala Sai Sundarasetty, Sebastian J. Theobald, Andreas Schneider, Laura Gerasch, Candida Deves Roth, Stephan Klöss, Ulrike Koehl, Constantin von Kaisenberg, Constanca Figueiredo, Haralampos Hatzikirou, Michael Meyer-Hermann, Renata Stripecke   +15 more
doaj   +1 more source

Immunization Dynamics on a 2-layer Network Model

, 2003
We introduce a 2-layer network model for the study of the immunization dynamics in epidemics. Spreading of an epidemic is modeled as an excitatory process in a small-world network (body layer) while immunization by prevention for the disease as a dynamic
Albert, Albert, Amaral, Anderson, Barabási, Cohen, Cohen, Dezső, Ebel, Eguíluz, Faloutsos, Hang-Hyun Jo, Hie-Tae Moon, Jeong, Kuperman, Liljeros, Mikhailov, Murray, Newman, Pastor-Satorras, Pastor-Satorras, Seung Ki Baek, Watts, Watts, Zanette   +24 more
core   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Risk Coupling Analysis of Metro Deep Foundation Pit Construction Based on Complex Networks

Buildings
The exacerbation of safety risk levels in metro deep foundation pit construction is attributed to the interactive coupling of numerous risk factors.
Jinyan Huang, Jun Fang, Jingchang Wang
doaj   +1 more source

An Iterative Cyclic Algorithm for Designing Vaccine Distribution Networks in Low and Middle-Income Countries

, 2019
The World Health Organization's Expanded Programme on Immunization (WHO-EPI) was developed to ensure that all children have access to common childhood vaccinations.
G Şahin, J Bland, P Yadav, S Melkote, S-I Chen, TM Melo   +5 more
core   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Underestimated cost of targeted attacks on complex networks

, 2017
The robustness of complex networks under targeted attacks is deeply connected to the resilience of complex systems, i.e., the ability to make appropriate responses to the attacks. In this article, we investigated the state-of-the-art targeted node attack
Antulov-Fantulin, Nino, Gleinig, Niels, Ren, Xiao-Long, Tolic, Dijana   +3 more
core   +2 more sources