Results 81 to 90 of about 51,241 (256)

Tumor Immunity in Rat Lymph Nodes Following Transplantation

Annals of Surgery, 1982
Inguinal lymph nodes in the Buffalo rat were autotransplanted to the popliteal fossa by an intact vascular pedicle or by microvascular anastomosis. These revascularized nodes had normal histology and made spontaneous afferent and efferent lymphatic reconnection with surrounding lymphatic vessels, as documented by ink and silicone rubber injection ...
J A, Rabson, S J, Geyer, G, Levine, W M, Swartz, J W, Futrell   +4 more
openaire   +3 more sources

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Cross-over behaviour in a communication network

, 2003
We address the problem of message transfer in a communication network. The network consists of nodes and links, with the nodes lying on a two dimensional lattice.
A.F. Rozenfeld, Albert-László Barabasi, Albert-László Barabasi, Alun L. Lloyd, Brajendra K. Singh, C. Moore, C.P. Warren, D.J. Watts, D.S. Callaway, E. Ahmed, F. Liljeros, H. Fuks, H. Fuks, J. Kleinberg, L.A.N. Amaral, M. Kuperman, M.E. Wilson, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, M.E.J. Newman, N.M. Ferguson, Neelima Gupte, P. Holme, R. Albert, R. Cohen, R. Milo, R. Pastor-Satorras, R. Pastor-Satorras, R.V. Sole, Robert M. May, Réka Albert, T. Ohira, T.M. Janaki, Victor M. Eguiluz, Y. Moreno, Z. Dezso   +38 more
core   +1 more source

Immune‐mediated antitumor effect of a transplanted lymph node [PDF]

International Journal of Cancer, 2018
Lymph node (LN) transplantation is a recognized method for reconstruction of the lymphatic system and is used in the clinical setting to treat lymphedema. However, it is unclear whether transplanted LNs contribute to immune surveillance. In our study, we investigated whether a single transplanted non‐vascularized LN, defined as a tumor‐draining ...
Taku Maeda, Toshihiko Hayashi, Hiroshi Furukawa, Daisuke Iwasaki, Kosuke Ishikawa, Emi Funayama, Naoki Murao, Masayuki Osawa, Akihiko Oyama, Yuhei Yamamoto   +9 more
openaire   +3 more sources

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Theories for influencer identification in complex networks

, 2018
In social and biological systems, the structural heterogeneity of interaction networks gives rise to the emergence of a small set of influential nodes, or influencers, in a series of dynamical processes.
A Guggiola, A Zeng, Alfredo Braunstein, B Min, B Min, B Viswanath, D Kempe, D Liben-Nowell, D Rybski, D Stauffer, D. Centola, DJ Watts, DJ Watts, Duncan S. Callaway, Ed Bullmore, EM Rogers, F Altarelli, F Morone, F Morone, F Morone, F Radicchi, G Lawyer, G Sabidussi, GL Nemhauser, H Kwak, HW Hethcote, J Kleinberg, J Leskovec, J Leskovec, JG Restrepo, K Klemm, K Roth, KI Hashimoto, L Katz, L Lü, L Lü, L Lü, L Muchnik, L. K. Gallos, Linton C. Freeman, M Kitsak, M Mézard, M Ramos, M Richardson, ME Newman, ME Newman, MS Granovetter, N. Eagle, Phillip Bonacich, R Pastor-Satorras, R Pastor-Satorras, Reuven Cohen, RM Karp, Réka Albert, S Luo, S Mugisha, S Pei, S Pei, S Pei, S Pei, S Pei, S Tang, S Yan, S Yan, SB Seidman, SD Reis, Sergey Brin, Sergey V. Buldyrev, T Martin, W Li, X Teng, X Teng, Y Hu, Y Liu, Y Liu   +74 more
core   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Role of imiquimod as adjuvant for vaccination against Leishmania major infection in BALB/c mice

Journal of Medical Microbiology and Infectious Diseases, 2013
Various adjuvants in combination with different antigens have been utilized as a vaccine candidate against leishmaniasis. However, the search for ideal adjuvants is still pursued due to the inefficiencies of current compounds.
Faramarz Dobakhti, Ghader Khalili, Hamid Mahmoudzadeh Niknam, Vahid Khaze, Fatemeh Partovi, Taraneh Naghibi Mahmoodabadi, Shahriar Aalinejad   +6 more
doaj  

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source