Results 61 to 70 of about 51,241 (256)

Pre-emptive spectral graph protection strategies on multiplex social networks

Applied Network Science, 2018
Constructing effective and scalable protection strategies over epidemic propagation is a challenging issue. It has been attracting interests in both theoretical and empirical studies. However, most of the recent developments are limited to the simplified
Arie Wahyu Wijayanto, Tsuyoshi Murata
doaj   +1 more source

IMMUNOLOGICAL AND PATHOLOGICAL STUDIES ON THE PURIFIED TOXIN OF PASTEURELLA MULTOCIDA ISOLATED FROM CALVES [PDF]

Veterinary Medical Journal - Giza, 2003
In the present study, a total of 235 buffalo calves (1-8 months of age) from different localities were investigated. They were grouped, 80 apparently healthy calves (group 1). 105 with respiratory manifestations (group 2) and 50 dead calves suffered from
HODA M ZAKI, EMAN M ABD EL MOTTALEB
doaj   +1 more source

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]

, 2013
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo, A Portela, AJ McMichael, Alexandria David, Andrew Pekosz, AS McKee, AT Heiny, B Zhou, CJ Wei, CS Ambrose, D Corti, D Grimm, D Zehn, DM Carragher, DT O’Hagan, E de Wit, F Crawford, F Rahman, GA Poland, GE Price, GT Belz, H Hikono, H Hohn, JB Ulmer, JE McElhaney, Jieru Wang, John W. Kappler, JP Christensen, JW Yewdell, K Thueng-in, L Guo, Laura Noges, LE Brown, LL Shu, M Schotsaert, M Wang, Megan K. L. MacLeod, MK MacLeod, MM Cox, MW LaMere, MW Lamere, N Garcon, Niyun Jin, P Marrack, Philippa Marrack, R Sebastian, RA Medina, SL Giannini, T Lambe, TM Wilkinson, U Kees, Y Furuya   +51 more
core   +3 more sources

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza infection

Frontiers in Immunology, 2023
The influenza virus is a persistent burden on global health, with seasonal vaccines providing incomplete protection. CD4+ T cells help shape B cell and antibody responses; however, the selectivity of help and the effect on various antigen-specific B cell
Danica F. Besavilla, Laura Reusch, Josue Enriquez, Karin Schön, Davide Angeletti, Davide Angeletti   +5 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Heterologous Booster Immunization Based on Inactivated SARS-CoV-2 Vaccine Enhances Humoral Immunity and Promotes BCR Repertoire Development

Vaccines
Recent studies have indicated that sequentially administering SARS-CoV-2 vaccines can result in increased antibody and cellular immune responses. In this study, we compared homologous and heterologous immunization strategies following two doses of ...
Xinghang Li, Fengyuan Zeng, Rong Yue, Danjing Ma, Ziyan Meng, Qi Li, Zhenxiao Zhang, Haobo Zhang, Yuansheng Liao, Yun Liao, Guorun Jiang, Heng Zhao, Li Yu, Dandan Li, Ying Zhang, Longding Liu, Qihan Li   +16 more
doaj   +1 more source

Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy

Case Reports in Dermatology, 2016
Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide.
Michelle S.Y. Ng, Alice Y.W. Foong, Mark J.A. Koh   +2 more
doaj   +1 more source

Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates

npj Vaccines, 2022
Despite the success of currently authorized vaccines for the reduction of severe COVID-19 disease risk, rapidly emerging viral variants continue to drive pandemic waves of infection, resulting in numerous global public health challenges.
Lochana M. Seenappa, Aniela Jakubowski, Martin P. Steinbuck, Erica Palmer, Christopher M. Haqq, Crystal Carter, Jane Fontenot, Francois Villinger, Lisa K. McNeil, Peter C. DeMuth   +9 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source