Results 51 to 60 of about 51,241 (256)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Inverse targeting -- an effective immunization strategy
, 2011 We propose a new method to immunize populations or computer networks against epidemics which is more efficient than any method considered before. The novelty of our method resides in the way of determining the immunization targets.
Herrmann, Hans J. +2 more
core +2 more sources
Advanced Functional Materials, EarlyView.We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li +6 more
wiley +1 more source
Rapid decay in the relative efficiency of quarantine to halt epidemics in networks
, 2017 Several recent studies have tackled the issue of optimal network immunization by providing efficient criteria to identify key nodes to be removed in order to break apart a network, thus preventing the occurrence of extensive epidemic outbreaks.
Castellano, Claudio, Strona, Giovanni
core +1 more source
SIRS Epidemics on Complex Networks: Concurrence of Exact Markov Chain and Approximated Models [PDF]
, 2015 We study the SIRS (Susceptible-Infected-Recovered-Susceptible) spreading processes over complex networks, by considering its exact $3^n$-state Markov chain model.
Hassibi, Babak, Ruhi, Navid Azizan
core +2 more sources
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Effective and scalable methods for graph protection strategies against epidemics on dynamic networks
Applied Network Science, 2019 Dynamic networks are networks with temporal relationship features which evolve over time by the inclusion and deletion of nodes and edges. Suppressing the epidemic spreading in such networks is quite challenging.
Arie Wahyu Wijayanto, Tsuyoshi Murata
doaj +1 more source
Immunization of Susceptible-Infected Model on Scale-Free networks
, 2006 In this paper, we investigate two major immunization strategies, random immunization and targeted immunization, of the susceptible-infected (SI) Model on the Barab\'{a}si-Albert (BA) networks.
Albert +27 more
core +1 more source
Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy [PDF]
Annual Review of Biomedical Engineering, 2016 Adaptive immune response consists of many highly regulated, multistep cascades that protect against infection while preserving the health of autologous tissue. The proper initiation, maintenance, and resolution of such responses require the precise coordination of molecular and cellular signaling over multiple time and length scales orchestrated by ...
Susan N, Thomas +2 more
openaire +2 more sources
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source