Results 31 to 40 of about 51,241 (256)
The Renal Lymph Node and Immune Tolerance to Filtered Antigens [PDF]
Journal of the American Society of Nephrology, 2013 The past decade has seen remarkable progress in our understanding of the immunologic responses associated with diseases of the kidney. In particular, the diversity of bone marrow-derived immune cells present in the kidney during health and disease has been detailed by many laboratories using ...
Pindjakova, J., Griffin, M. D.
openaire +3 more sources
A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice. [PDF]
PLoS ONE, 2018 T cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naïve CD4+ and CD8+ T cells declines.
Neha R Deshpande +4 more
doaj +1 more source
Tumour-induced immune modulation of sentinel lymph nodes [PDF]
Nature Reviews Immunology, 2006 Sentinel lymph nodes (SLNs), being the first nodes to receive lymph from a primary tumour and the preferential site of initial tumour metastases, are intensively exposed to the bioactive products of tumour cells and other associated cells. This makes them ideal for studies of the factors that determine selective tissue susceptibility to metastases.
Alistair J, Cochran +5 more
openaire +2 more sources
Immunization of Real Complex Communication Networks [PDF]
, 2005 Most communication networks are complex. In this paper, we address one of the fundamental problems we are facing nowadays, namely, how we can efficiently protect these networks.
Echenique, Pablo +2 more
core +6 more sources
Effects of immunization in small-world epidemics [PDF]
, 2001 The propagation of model epidemics on a small-world network under the action of immunization is studied. Although the connectivity in this kind of networks is rather uniform, a vaccination strategy focused on the best connected individuals yields a ...
Kuperman, Marcelo, Zanette, Damian H.
core +1 more source
Worst-Case Scenarios for Greedy, Centrality-Based Network Protection Strategies [PDF]
, 2014 The task of allocating preventative resources to a computer network in order to protect against the spread of viruses is addressed. Virus spreading dynamics are described by a linearized SIS model and protection is framed by an optimization problem which
Preciado, Victor M., Zargham, Michael
core +1 more source
Immune Checkpoint Therapy: Tumor Draining Lymph Nodes in the Spotlights [PDF]
International Journal of Molecular Sciences, 2021 Tumor-draining lymph nodes play a paradoxical role in cancer. Surgeons often resect these sentinel lymph nodes to determine metastatic spread, thereby enabling prognosis and treatment. However, lymph nodes are vital organs for the orchestration of immune responses, due to the close encounters of dedicated immune cells.
Marieke F. Fransen +2 more
openaire +4 more sources
Cell Reports, 2019 Summary: The first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we tracked the kinetics of the primary immune response in
Colin Havenar-Daughton +19 more
doaj +1 more source
Active targeted delivery of immune therapeutics to lymph nodes [PDF]
Current Opinion in Organ Transplantation, 2018 Organ transplantation is a life-saving procedure and the only option for patients with end-organ failure. Immune therapeutics have been key to the success of organ transplantation. However, immune therapeutics are still unable to eliminate graft rejection and their toxicity has been implicated in poorer long-term transplant outcomes.
Baharak, Bahmani +3 more
openaire +2 more sources
Nature Communications, 2023 The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple sclerosis has generated considerable interest in the development of an effective vaccine against EBV.
Vijayendra Dasari +15 more
doaj +1 more source