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Plant immunity: the EDS1 regulatory node [PDF]
ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) and its interacting partner, PHYTOALEXIN DEFICIENT 4 (PAD4), constitute a regulatory hub that is essential for basal resistance to invasive biotrophic and hemi-biotrophic pathogens. EDS1 and PAD4 are also recruited by Toll-Interleukin-1 receptor (TIR)-type nucleotide binding-leucine rich repeat (NB-LRR) proteins
Wiermer, M., Feys, B., Parker, J.
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Evaluation of the Sentinel Immunized Node for Immune Monitoring of Cancer Vaccines [PDF]
We hypothesized that lymph nodes draining sites of cutaneous vaccination could be identified by sentinel node biopsy techniques, and that measuring T-cell response with lymphocytes obtained from these lymph nodes would provide a more sensitive measure of immunogenicity than would the same measurement made with peripheral blood lymphocytes (PBL).ELISpot
Craig L, Slingluff +12 more
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Lymph Node Immune Profiles as Predictive Biomarkers for Immune Checkpoint Inhibitor Response [PDF]
The need for predictive biomarkers that can accurately predict patients who will respond to immune checkpoint inhibitor (ICI) immunotherapies remains a clinically unmet need. The majority of research efforts have focused on expression of immune-related markers on the tumour and its associated tumour microenvironment (TME).
Emily F. Goode +4 more
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Node Immunization with Non-backtracking Eigenvalues
The non-backtracking matrix and its eigenvalues have many applications in network science and graph mining, such as node and edge centrality, community detection, length spectrum theory, graph distance, and epidemic and percolation thresholds. Moreover, in network epidemiology, the reciprocal of the largest eigenvalue of the non-backtracking matrix is ...
Leo Torres 0003 +3 more
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IFNγ is a central node of cancer immune equilibrium
Tumors in immune equilibrium are held in balance between outgrowth and destruction by the immune system. The equilibrium phase defines the duration of clinical remission and stable disease, and escape from equilibrium remains a major clinical problem.
Michael J. Walsh +7 more
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Mesenteric lymph nodes at the center of immune anatomy [PDF]
The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live ...
Macpherson, Andrew J., Smith, Karen
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Growth and Immune Evasion of Lymph Node Metastasis [PDF]
Cancer patients with lymph node (LN) metastases have a worse prognosis than those without nodal disease. However, why LN metastases correlate with reduced patient survival is poorly understood. Recent findings provide insight into mechanisms underlying tumor growth in LNs.
Dennis Jones +5 more
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Avalanche-size distribution of Cayley tree
Attacks on networks is a very important issue in developing strategies of eradicating spreads of malicious phenomena in networks, such as epidemics and fake information. This field of research is referred to as networks immunization.
Amikam Patron
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Effective Graph Protection Method to Prevent the Spreading of Attacks in Networks
Networks are fundamental models for representing and analyzing the structures of real-world systems. For instance, in social networks, nodes are used to represent users and edges represent the connection between users.
A. W. Wijayanto, A. Pindarwati
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Dynamics-Preserving Graph Embedding for Community Mining and Network Immunization
In recent years, the graph embedding approach has drawn a lot of attention in the field of network representation and analytics, the purpose of which is to automatically encode network elements into a low-dimensional vector space by preserving certain ...
Jianan Zhong, Hongjun Qiu, Benyun Shi
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