Results 71 to 80 of about 627,745 (234)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Node importance evaluation method based on multi-attribute decision-making model in wireless sensor networks

EURASIP Journal on Wireless Communications and Networking, 2019
Identifying important nodes is very crucial to design efficient communication networks or contain the spreading of information such as diseases and rumors. The problem is formulated as follows: given a network, which nodes are the more important?
Rongrong Yin, Xueliang Yin, Mengdi Cui, Yinghan Xu   +3 more
doaj   +1 more source

Range-based attack on links in scale-free networks: are long-range links responsible for the small-world phenomenon?

, 2003
The small-world phenomenon in complex networks has been identified as being due to the presence of long-range links, i.e., links connecting nodes that would otherwise be separated by a long node-to-node distance.
A. Broder, A.-L. Barabási, Adilson E. Motter, D.J. Watts, D.S. Callaway, F. Liljeros, H. Jeong, K.-I. Goh, M. Girvan, M.E.J. Newman, M.E.J. Newman, P. Erdös, P. Holme, R. Albert, R. Albert, R. Cohen, R.V. Solé, S.A. Pandit, S.N. Dorogovtsev, Takashi Nishikawa, V. Latora, Ying-Cheng Lai   +21 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relative Node Importance in complex networks

, 2023
<p><em>This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible.</em> </p>
openaire   +1 more source

Fast Distributed PageRank Computation

, 2015
Over the last decade, PageRank has gained importance in a wide range of applications and domains, ever since it first proved to be effective in determining node importance in large graphs (and was a pioneering idea behind Google's search engine).
Andersen, Anisur Rahaman Molla, Atish Das Sarma, Avrachenkov, Bahmani, Bahmani, Berkhin, Bianchini, Brin, Cook, Das Sarma, Das Sarma, Das Sarma, Eli Upfal, Gopal Pandurangan, Grolmusz, Iván, Langville, Mitzenmacher, Page, Perra, Sankaralingam, Shi, Wang   +23 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Finding vital node by node importance evaluation matrix in complex networks

Acta Physica Sinica, 2012
In order to evaluate the node importance in complex network, considering the disadvantages of node deletion method, node contraction method and betweenness method, through defining the node efficiency and the node importance evaluation matrix, a method to find the vital node in complex networks is proposed by using the node importance evaluation matrix.
null Zhou Xuan, null Zhang Feng-Ming, null Li Ke-Wu, null Hui Xiao-Bin, null Wu Hu-Sheng   +4 more
openaire   +1 more source