Results 81 to 90 of about 627,745 (234)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Cancer, 2000 Although, to the authors' knowledge, no prospective randomized clinical trial has demonstrated improvement in survival following the radical dissection of lymph nodes in the treatment of cancer patients, lymphadenectomy is still routinely performed for curative purposes.
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Semi-Local Integration Measure for Directed Graphs
MathematicsDirected and weighted graphs can be used for many real-world applications to model and analyse the quality and structure of communication within the system, the distribution and flow of information, and various resources, dependencies, resilience, etc ...
Tajana Ban Kirigin +1 more
doaj +1 more source
New Metrics for Node Importance Evaluation in Occupational Injury Network
IEEE Access, 2019 Complex networks provide a convenient way to model the process of occupational injury occurrence at the system level, and node importance metrics are usually employed to quantify the influence of the factors leading to injuries.
Xinbo Ai
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Evaluation method for network invulnerability based on shortest route number
Tongxin xuebao, 2009 Fully connecting network has the best invulnerability,and also the shortest route numbers between nodes is important for network invulnerability.Therefore,by calculating shortest route numbers and comparing the topology dif-ference between target network
RAO Yu-ping, LIN Jing-yu, HOU De-ting
doaj +2 more sources
Power communication website bandwidth estimation method based on position weighting
Dianxin kexue, 2018 A power communication network site point communication bandwidth estimation method was proposed,which was related to the field of power communication networks.Firstly,according to a topology diagram of a power communication network,the local importance ...
Zhengjia ZHU +4 more
doaj +2 more sources
EnergiesAs power grids continue to expand in scale, the occurrence of cascading failures within them can lead to significant economic losses. Therefore, assessing the criticality of grid nodes is crucial for ensuring the secure and stable operation of power ...
Guowei Sun +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source