Results 21 to 30 of about 968,923 (219)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Modeling Method for Vibration Characteristics Analysis of Composite-Laminated Rotationally Stiffened Plate

Shock and Vibration
The composite-laminated rotationally stiffened plate is widely applied in aviation, aerospace, ship, machinery, and other fields. For structural design and optimization, to investigate the vibration characteristics is important. In this paper, a modeling
Hong Zhang, Yiqun Ding, Lin He, Changgeng Shuai, Chao Jiang   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Effect of a Flexible Electrode on the Electro Deformability of an Actuating Unit of a MDI-Polyurethane Composite Fiber Membrane Filled with BaTiO₃

Membranes, 2022
The electro deformability of an actuating unit of a polyurethane dielectric elastomer (PUDE) is affected by many factors. The agglomeration of dielectric fillers faced by the traditional dielectric modification methods will lead to the instability of the
Gang Lu, Changgeng Shuai, Yinsong Liu, Xue Yang, Xiaoyang Hu   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Numerical simulation of temperature variation in water layer induced by thermal jet in weak stratified environment

AIP Advances, 2022
In order to explore the rising and diffusing path of an underwater thermal jet and the temperature variation of each water layer in the typical ocean thermohaline stratified environment, a three-dimensional mass-heat transport model of the thermal jet in
Feiyang Luo, Changgeng Shuai, Yongcheng Du, Jianguo Ma   +3 more
doaj   +1 more source

Preparation and Dielectric Sensitivity of Polyurethane Composite Fiber Membrane Filled with BaTiO₃

Membranes, 2022
Polyurethane dielectric elastomer (PUDE) is considered a potential underwater flexible actuator material due to its excellent designability and environmental tolerance at the molecular level. Currently, the application of the polyurethane elastomer as an
Gang Lu, Changgeng Shuai, Yinsong Liu, Xue Yang, Xiaoyang Hu   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Bearing Health Evaluation Model using Segmentive Technique and Cosine KNN in Different Loading Situations [PDF]

ITM Web of Conferences
Bearing faults are a common cause of machinery failure, and bearing vibration analysis is critical in preventing any unacceptable consequences of such failures.
Yap J.S., Lim M.H., Leong M. Salman
doaj   +1 more source