Results 31 to 40 of about 968,923 (219)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Enhanced Bearing Fault Analysis under Inconstant Loads Conditions by Cosine Weighted K-Nearest Neighbours Model [PDF]

ITM Web of Conferences
Bearing faults often lead to machinery failures, underscoring the importance of analyzing bearing vibrations to avert undesirable consequences. Leveraging Artificial Intelligence (AI) in this context benefits from the strides in intelligent data ...
Yap J.S., Lim M.H., Leong M. Salman
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Review of Underground Storage Tank Condition Monitoring Techniques

MATEC Web of Conferences, 2019
This article aims to provide a comprehensive review on the condition monitoring techniques of underground storage tanks (UST). Generally, the UST has long been a favourite toxic substance reservation apparatus, thanks to its large capacity and minimum ...
Ching Sheng Ooi, Ngui Wai Keng, Kar Hoou Hui, Meng Hee Lim, Leong Mohd. Salman   +4 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Adaptive Narrowband Compensation Algorithm for Active Control of the Pressure Pulsation Line Spectrum in A Liquid Pipeline System

Shock and Vibration
Active noise control technology provides a means for actively controlling pipeline pulsations. The control signal emitted by the secondary source feeds back into the reference input signal, thereby generating a pulsation coupling phenomenon.
Qichao Liu, Wenjing Yu, Guo Cheng
doaj   +1 more source

Optimzation design of resonance changer for marine propulsion shafting in longitudinal vibration

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] The transmission path of the longitudinal vibration of propeller shafting can be changed and the base response attenuated via a Resonance Changer(RC)integrated in the thrust bearing, enabling the natural frequency of the shafting to be ...
Hu Zechao, He Lin, Xu Wei, Li Zhengmin, Zhao Xingqian   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source