Results 41 to 50 of about 922,338 (264)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Comparison of Finite Element Analysis (With Additional Aspects) For Predicting the Noise and Vibration for Railway Project in Malaysia

MATEC Web of Conferences, 2019
This paper is about predicting the noise and vibrations for railways project in Malaysia by using Finite Element Analysis method. In recent years, Malaysia is massively developing railways industry.
Yeo Siang Chuan, Lim Meng Hee, Eng Hoe Cheng   +2 more
doaj   +1 more source

Optimzation design of resonance changer for marine propulsion shafting in longitudinal vibration

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] The transmission path of the longitudinal vibration of propeller shafting can be changed and the base response attenuated via a Resonance Changer(RC)integrated in the thrust bearing, enabling the natural frequency of the shafting to be ...
Hu Zechao, He Lin, Xu Wei, Li Zhengmin, Zhao Xingqian   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Adaptive Narrowband Compensation Algorithm for Active Control of the Pressure Pulsation Line Spectrum in A Liquid Pipeline System

Shock and Vibration
Active noise control technology provides a means for actively controlling pipeline pulsations. The control signal emitted by the secondary source feeds back into the reference input signal, thereby generating a pulsation coupling phenomenon.
Qichao Liu, Wenjing Yu, Guo Cheng
doaj   +1 more source

Review of Underground Storage Tank Condition Monitoring Techniques

MATEC Web of Conferences, 2019
This article aims to provide a comprehensive review on the condition monitoring techniques of underground storage tanks (UST). Generally, the UST has long been a favourite toxic substance reservation apparatus, thanks to its large capacity and minimum ...
Ching Sheng Ooi, Ngui Wai Keng, Kar Hoou Hui, Meng Hee Lim, Leong Mohd. Salman   +4 more
doaj   +1 more source

Free vibration characteristics of cord-reinforced air spring with winding formation under preload conditions

AIP Advances, 2023
A precise transfer matrix was employed to analyze the free vibration characteristics of a cord-reinforced air spring with winding formation under preload conditions. The air spring was abstracted as a rotary combined shell structure with variable winding
Yu-Qiang Cheng, Lin He, Chang-Geng Shuai, Hua Gao, Jian-Guo Ma   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source