Results 41 to 50 of about 968,923 (219)

Free vibration characteristics of cord-reinforced air spring with winding formation under preload conditions

AIP Advances, 2023
A precise transfer matrix was employed to analyze the free vibration characteristics of a cord-reinforced air spring with winding formation under preload conditions. The air spring was abstracted as a rotary combined shell structure with variable winding
Yu-Qiang Cheng, Lin He, Chang-Geng Shuai, Hua Gao, Jian-Guo Ma   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Comparison of Finite Element Analysis (With Additional Aspects) For Predicting the Noise and Vibration for Railway Project in Malaysia

MATEC Web of Conferences, 2019
This paper is about predicting the noise and vibrations for railways project in Malaysia by using Finite Element Analysis method. In recent years, Malaysia is massively developing railways industry.
Yeo Siang Chuan, Lim Meng Hee, Eng Hoe Cheng   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intelligent Alignment Control for Floating Raft Air Spring Mounting System Under Coupled Hull–Raft Deformation

Journal of Marine Science and Engineering
Shaft alignment is adversely affected by the increasingly severe coupled hull–raft deformation in deep-diving, highly integrated submersibles, thereby compromising operational safety and potentially amplifying vibration noise.
Jian-Wei Cheng, Wen-Jun Bu, Ze-Chao Hu, Jun-Qiang Fu, Hong-Rui Zhang, Liang Shi   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Study on the influence of working condition variation on lubrication characteristics of EHA internal pump

Scientific Reports
The operational characteristics of Electro-Hydraulic Actuator(EHA) result in the EHA internal pump facing complex conditions of variable speed, pressure and even direction, resulting in poor lubrication state of friction pairs.
Yantao Zhang, Zongbin Chen, Jun Che, Jian Liao   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ESL-YOLO: Edge-Aware Side-Scan Sonar Object Detection with Adaptive Quality Assessment

Journal of Marine Science and Engineering
Focusing on the problem of insufficient detection accuracy caused by blurred target boundaries, variable scales, and severe noise interference in side-scan sonar images, this paper proposes a high-precision detection network named ESL-YOLO, which ...
Zhanshuo Zhang, Changgeng Shuai, Chengren Yuan, Buyun Li, Jianguo Ma, Xiaodong Shang   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source