Results 61 to 70 of about 2,665,841 (300)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
AIP Advances, 2023 A precise transfer matrix was employed to analyze the free vibration characteristics of a cord-reinforced air spring with winding formation under preload conditions. The air spring was abstracted as a rotary combined shell structure with variable winding
Yu-Qiang Cheng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
MATEC Web of Conferences, 2019 This paper is about predicting the noise and vibrations for railways project in Malaysia by using Finite Element Analysis method. In recent years, Malaysia is massively developing railways industry.
Yeo Siang Chuan +2 more
doaj +1 more source
International Journal of Environmental Research and Public Health, 2018 To update the current state of evidence and assess its quality, we conducted a systematic review on the effects of environmental noise exposure on the cardio-metabolic systems as input for the new WHO environmental noise guidelines for the European ...
Elise van Kempen +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Scientific ReportsThe operational characteristics of Electro-Hydraulic Actuator(EHA) result in the EHA internal pump facing complex conditions of variable speed, pressure and even direction, resulting in poor lubrication state of friction pairs.
Yantao Zhang +3 more
doaj +1 more source
Journal of Marine Science and EngineeringShaft alignment is adversely affected by the increasingly severe coupled hull–raft deformation in deep-diving, highly integrated submersibles, thereby compromising operational safety and potentially amplifying vibration noise.
Jian-Wei Cheng +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source