Results 51 to 60 of about 11,122,120 (305)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Noise responses before and after noise abatement measures in a residential intervention project

open access: yes, 2015
In a residential area exposed to road traffic noise a socio-acoustic longitudinal study was conducted to investigate the effects of a large intervention project on acoustical conditions and resident's noise responses.
Kihlman, Tor   +10 more
core   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Awakening effects of church bell noise: Geographical extrapolation of the results of a polysomnographic field study 1

open access: yesNoise and Health, 2013
Based on a previously published exposure-effect model of Electroencephalography (EEG)-awakening reactions (AWR) due to nightly church bell noise events, as well as on geocoded building and population data, we estimated the total number of the church bell
Sarah Omlin, Mark Brink
doaj   +1 more source

Contribution of emissions to concentrations: the TAGGING 1.0 submodel based on the Modular Earth Submodel System (MESSy 2.52) [PDF]

open access: yesGeoscientific Model Development, 2017
Questions such as what is the contribution of road traffic emissions to climate change? or what is the impact of shipping emissions on local air quality?
V. Grewe   +5 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Perceptual effects of noise mitigation

open access: yes, 2014
Noise mitigation reduces the audibility of a noise source at the location of the receiver, making the source less annoying and less likely to interfere with activities, such as sleep, rest, and speech. Many mitigation methods change temporal and spectral
Nilsson, Mats E.,   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Strength of noise effects on memory as a function of noise source and age

open access: yes, 2005
The objectives in this paper were to analyse noise effects on episodic and semantic memory performance in different age groups, and to see whether age interacted with noise in their effects on memory.
Hygge, S.   +3 more
core   +1 more source

Influence of Gaussian noise and Levy noise on the phase dynamics of the ensemble of Kuramoto-like oscillators of first and second order [PDF]

open access: yesИзвестия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this study is to determine the stability threshold of the dynamic modes of the ensemble of phase Kuramoto-like oscillators, describing the behavior of a simple power grid model with a ring topology, under the external influence of Gaussian
Arinushkin, Pavel Alekseevich   +2 more
doaj   +1 more source

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