Results 71 to 80 of about 755,676 (315)

Trailing Edge Noise Reduction by Passive and Active Flow Controls [PDF]

open access: yes, 2014
This paper presents the results on the use of porous metal foams (passive control) and dielectric barrier surface plasma actuations (active control) for the reduction of vortex shedding tonal noises from the nonflat plate type trailing edge serration in ...
Kim, JH   +7 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Detectability index measures of binaural masking level difference across populations of inferior colliculus neurons.

open access: yes, 1997
In everyday life we continually need to detect signals against a background of interfering noise (the “cocktail party effect”): a task that is much easier to accomplish using two ears.
Palmer, AR, McAlpine, D, Jiang, D
core  

Noise Levels In An Urban Asian School Environment [PDF]

open access: yes, 2015
Background noise is known to adversely affect speech perception and speech recognition. High levels of background noise in school classrooms may affect student learning, especially for those pupils who are learning in a second language.
McPherson, DB   +4 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

On rules for stopping the conjugate gradient type methods in ill‐posed problems

open access: yesMathematical Modelling and Analysis, 2007
We consider stopping rules in conjugate gradient type iteration methods for solving linear ill‐posed problems with noisy data. The noise level may be known exactly or approximately or be unknown. We propose several new stopping rules, mostly for the case
Uno Hämarik, Reimo Palm
doaj   +1 more source

The Effect of Noise Reduction Measures on the Perception of Railway Noise

open access: yes, 2015
The A-weighted sound pressure level is a commonly used quantity to assess the effect of noise reduction measures. However, psychoacoustic variables, in particular loudness, are assumed to better explain perceived annoyance.
Kaseß, Christian   +3 more
core  

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