Results 31 to 40 of about 1,519,506 (293)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Numerical Study on Aerodynamic Noise Reduction of Pantograph
Applied Sciences, 2022 A hybrid method incorporating the simulations of noise sources with delayed detached eddy simulation (DDES) and calculations of far-field noise with the Ffowcs Williams–Hawkings (FW-H) equation is used to study the suppression technique for the ...
Fangcheng Shi +3 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Psychophysical evidence for two routes to suppression before binocular summation of signals in human vision [PDF]
, 2007 Visual mechanisms in primary visual cortex are suppressed by the superposition of gratings perpendicular to their preferred orientations. A clear picture of this process is needed to (i) inform functional architecture of image-processing models, (ii ...
Baker, D.H. +8 more
core +1 more source
Noise Suppression With Cryogenic Resonators
IEEE Microwave and Wireless Components Letters, 2021 We show that fast technical fluctuations of microwave signals can be strongly suppressed by cryogenic resonators. The experiments were carried out with sapphire resonators cooled to approximately 6 K at frequencies around 11 GHz. Each sapphire crystal was shaped like a spindle with the rotational and crystal axes aligned within a degree.
Ivanov, Eugene N., Tobar, Michael E.
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Are the comfort classes noise and vibration levels on board really suitable?
, 2021 In shipbuilding industry, comfort is a relevant issue both for crew members and passengers. A comfortable environment enables crew members to perform accurately their tasks and it is an effective factor contributing to the satisfaction of passengers ...
Flavia D'Agostin +2 more
core +1 more source
Strong Spurious Noise Suppression for an FMCW SAR [PDF]
Radioengineering, 2016 To meet the miniature requirement, a frequency modulated continuous wave synthetic aperture radar (FMCW SAR) puts tight constraint on the compactness, which causes the interference of narrow band noise.
H. Tian, W.G. Chang, X.Y. Li, Z.H. Liu
doaj