Results 131 to 140 of about 11,770 (301)
Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang +8 more
wiley +1 more source
ACM SIGLOG News, 2016 Programming languages abound with features making use of names in various ways. There is a mathematical foundation for the semantics of such features which uses groups of permutations of names and the notion of the support of an object with respect to the action of such a group.
openaire +2 more sources
Advanced Science, EarlyView.This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang +14 more
wiley +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Advanced Science, EarlyView.CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai +15 more
wiley +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
Nominative-marked phrases in Japanese tough constructions
, 2012 Producción CientíficaIn this paper we conduct a detailed examination of the tough construction in Japanese with the main focus on some types of nominative case particles "ga".
Valverde Ibáñez, Pilar, Ohtani, Akira
core
Subject agreement in Kalmyk: Implications for nominative case assignment
This paper investigates the nature of nominative case assignment and its relationship to agreement and finiteness in Kalmyk Oirat (or Kalmyk), a variety of the Oirat language (Mongolic) spoken in the Republic of Kalmykia, Russia and in diasporic ...
Jie Lim, Jun
core +1 more source
Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery
Advanced Science, EarlyView.DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong +8 more
wiley +1 more source