Results 41 to 50 of about 10,661 (279)

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

open access: yesAdvanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim   +7 more
wiley   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

Set-theoretic Analysis of Nominative Data [PDF]

open access: yesComputer Science Journal of Moldova, 2015
In the paper we investigate the notion of nominative data that can be considered as a general mathematical model of data used in computing systems. The main attention is paid to flat nominative data called nominative sets.
Volodymyr G. Skobelev   +2 more
doaj  

On the subject-orientation of the dispositional middle construction

open access: yesLinguistics, 2023
This article argues against the claim that the dispositional middle construction is always subject-oriented, by discussing dispositional constructions in Japanese and impersonal middle constructions formed with the causative verb lassen ‘let’ in German ...
Oya Toshiaki
doaj   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

open access: yesAdvanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son   +2 more
wiley   +1 more source

Ergative Verbs in English and Arabic

open access: yesمجلة كلية الفقه
Ergativity is one the distinctive features that differentiate between two types of languages: ergative languages such as Basque and Eskimo languages and non-ergative languages such as Indo European languages.
Asst. Prof. Dr. Ameer Ali Hussein Al Majtoomy   +1 more
doaj   +1 more source

A checagem de caso dos múltiplos sintagmas nominativos – GA, a relação com o foco da sentença e as restrições sobre a small clause

open access: yesCadernos de Estudos Lingüísticos, 2011
The central proposal of this paper is to present the checking process of the nominativ phrase –GA, in Japanese Language, in sentences with one or more than one nominative phrases.
Cristina Yukie Miyaki Fuchs
doaj   +1 more source

Possessor raising and structural variations within the vP domain

open access: yesGlossa, 2023
In this paper, we analyze external possessors in Brazilian Portuguese, showing that those realizing Nominative-Case (Nominative-possessors) are not syntactically uniform, varying derivationally.
doaj   +2 more sources

Bare Nominals

open access: yes, 2017
Bare nominals (also called “bare nouns”) are nominal structures without an overt article or other determiner. The distinction between a bare noun and a noun that is part of a larger nominal structure must be made in context: Milk is a bare nominal in I bought milk, but not in I bought the milk.
Le Bruyn, B.S.W.   +2 more
openaire   +2 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy