Results 41 to 50 of about 2,882 (264)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Nominative Potential of the Word Anguish

RUDN Journal of Language Studies, Semiotics and Semantics
The prerequisite for resolving the question of the nominative system is the recognition of nominative activity as a subject of linguistic science. The function of nominative activity, which consists of producing nominative units that verbalize and ...
Lazzat K. Zhanalina, Irina V. Kotlyarova
doaj   +1 more source

КОМУНІКАТИВНО-ПРАГМАТИЧНІ ВИМІРИ НОМІНАТИВНИХ РЕЧЕНЬ В АНГЛОМОВНОМУ ХУДОЖНЬОМУ ТЕКСТІ / COMMUNICATIVE AND PRAGMATIC DIMENSIONS OF NOMINATIVE SENTENCES IN ENGLISH LITERARY TEXT

Актуальні питання суспільних наук та історії медицини, 2017
Томусяк А. Коммуникативно-прагматические измерения номинативных предложений в англоязычном художественном тексте. В статье проведен анализ односложных номинативных предложений с коммуникативно-прагматической точки зрения.
Аліна ТОМУСЯК
doaj   +1 more source

The Nominative Field of HAPPINESS Concept in the Middle English and Modern English Periods

Дискурс, 2023
Introduction. The article presents the result of the diachronical research of HAPPINESS concept nominative field. The research was conducted on the basis of English explanatory dictionaries and texts of corpus databases, using the methods of corpus ...
E. A. Nilsen, E. A. Okulova
doaj   +1 more source

Nominal SOS

Electronic Notes in Theoretical Computer Science, 2012
AbstractPlotkinʼs style of Structural Operational Semantics (SOS) has become a de facto standard in giving operational semantics to formalisms and process calculi. In many such formalisms and calculi, the concepts of names, variables and binders are essential ingredients. In this paper, we propose a formal framework for dealing with names in SOS.
Matteo Cimini, Mohammad Reza Mousavi 0001, Michel A. Reniers, Murdoch James Gabbay   +3 more
openaire   +2 more sources

Nominal rewriting

Information and Computation, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Maribel Fernández, Murdoch Gabbay
openaire   +2 more sources

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source