Results 51 to 60 of about 10,661 (279)
Advanced Science, EarlyView.Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang +12 more
wiley +1 more source
Phasal transfer and anti-locality: Movement of objects in Japanese
Glossa, 2023 In this paper, based on an analysis of the scope properties of objects in Japanese, I argue that (i) an entire phase is transferred when a higher phase is completed, and (ii) the movement of objects and adjuncts is constrained by anti-locality.
Masahiko Takahashi
doaj +2 more sources
Advanced Science, EarlyView.Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang +14 more
wiley +1 more source
Актуальні питання суспільних наук та історії медицини, 2017 Томусяк А. Коммуникативно-прагматические измерения номинативных предложений в англоязычном художественном тексте. В статье проведен анализ односложных номинативных предложений с коммуникативно-прагматической точки зрения.
Аліна ТОМУСЯК
doaj +1 more source
Advanced Science, EarlyView.A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin +6 more
wiley +1 more source
The Nominative Field of HAPPINESS Concept in the Middle English and Modern English Periods
Дискурс, 2023 Introduction. The article presents the result of the diachronical research of HAPPINESS concept nominative field. The research was conducted on the basis of English explanatory dictionaries and texts of corpus databases, using the methods of corpus ...
E. A. Nilsen, E. A. Okulova
doaj +1 more source
Advanced Science, EarlyView.Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang +12 more
wiley +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Dialectica, 2005 The aim of the present paper is twofold. One task is to argue that our use of the numerical vocabulary in theory and applications determines the reference of the numerical terms more precisely than up to isomorphism. In particular our use of the numerical vocabulary in modal and counterfactual contexts of application excludes contingent existents as ...
openaire +2 more sources
Advanced Science, EarlyView.This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source