Results 161 to 170 of about 116,458 (273)

Single‐Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions

open access: yesCancer Science, Volume 117, Issue 3, Page 597-612, March 2026.
This study is the first to identify a novel neutrophil subpopulation, N4, that is closely associated with the progression of cervical cancer. Characterized by high PLAU expression and specific interactions with tumor cells, N4 neutrophils were shown to promote tumor growth and immune modulation.
Ze Wang   +7 more
wiley   +1 more source

Phase 1/2 Study of Crizotinib in Children With Relapsed/Refractory ALK‐Positive Anaplastic Large Cell Lymphoma or Neuroblastoma in Japan

open access: yesCancer Science, Volume 117, Issue 3, Page 777-786, March 2026.
The safety and antitumor activity of crizotinib at a dose of 165 mg/m2 BID were evaluated in 16 patients with ALK‐positive ALCL in Japan. The most common grade 3 or 4 adverse event was neutropenia. The steady‐state Cmax and AUCtau of crizotinib at 165 mg/m2 BID were higher than expected. The objective response rate was 72.7% (90% CI, 43.6%–92.1%) among
Tetsuya Mori   +12 more
wiley   +1 more source

Nomograms

open access: yesThe Journal of ExtraCorporeal Technology, 1994
openaire   +1 more source

Nomogram for Anaesthetic Uptake [PDF]

open access: yesAnaesthesia and Intensive Care, 1994
H J, Lowe, J F, Viljoen
openaire   +2 more sources

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

open access: yesCell Proliferation, Volume 59, Issue 3, March 2026.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping   +7 more
wiley   +1 more source

Mechanism of ITGB2 in Osteoclast Differentiation in Osteoarthritis

open access: yesCell Proliferation, Volume 59, Issue 3, March 2026.
In osteoclast precursors, higher ITGB1 than ITGB2 expression increases ITGA2‐ITGB1 integrin. In OA, extracellular signals upregulate ITGB2 and downregulate ITGB1, enhancing ITGA2‐ITGB2 integrin. This activates Rac1 to Rac‐GTP, driving osteoclast differentiation. Hyperactive subchondral osteoclasts accelerate OA progression.
Yang Yang   +16 more
wiley   +1 more source

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