Results 121 to 130 of about 515,543 (292)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Application of Organic Acid Salts as Feed Additives in Some Aquatic Organisms: Potassium Diformate
FishesAntibiotics are the primary measures employed in the prevention and treatment of diseases in aquaculture. However, the frequent utilization of antibiotics can significantly impact the growth and reproduction of aquatic organisms, resulting in water ...
Junxiang Chen +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Inconsistency and non-additive Choquet integration in the Analytic Hierarchy Process [PDF]
We propose to extend the aggregation scheme of Saaty’s AHP, from the stan- dard weighted averaging to the more general Choquet integration. In our model, a measure of inconsistency between criteria is derived from the main pairwise comparison matrix and ...
Ricardo Alberto Marques Pereira +1 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On The Integral Representation of Strictly Continuous Set-Valued Maps
International Journal of Analysis and Applications, 2015 Let T be a completely regular topological space and C(T) be the space of bounded, continuous real-valued functions on T. C(T) is endowed with the strict topology (the topology generated by seminorms determined by continuous functions vanishing at in_nity)
Anaté K. Lakmon, Kenny K. Siggini
doaj +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On attitude polarization under Bayesian learning with non-additive beliefs [PDF]
Ample psychological evidence suggests that people’s learning behavior is often prone to a "myside bias" or "irrational belief persistence" in contrast to learning behavior exclusively based on objective data.
Alexander Ludwig, Alexander Zimper
core +1 more source
EntropyDeep learning has made significant strides, driving advances in areas like computer vision, natural language processing, and autonomous systems. In this paper, we further investigate the implications of the role of additive shortcut connections, focusing
Zhaoyan Lyu, Miguel R. D. Rodrigues
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source