Results 121 to 130 of about 188,535 (344)

FT3/FT4 ratio predicts non-alcoholic fatty liver disease independent of metabolic parameters in patients with euthyroidism and hypothyroidism

Clinics, 2016
OBJECTIVE: This study was performed to evaluate the effects of metabolic parameters and thyroid dysfunction on the development of non-alcoholic fatty liver disease (NAFLD).
Fatma Yahyaoğlu Gökmen, Süleyman Ahbab, Hayriye Esra Ataoğlu, Betül Çavuşoğlu Türker, Faik Çetin, Fatih Türker, Rabia Yahyaoğlu Mamaç, Mustafa Yenigün   +7 more
doaj   +1 more source

Comparison of magnetic resonance spectroscopy, proton density fat fraction and histological analysis in the quantification of liver steatosis in children and adolescents [PDF]

, 2016
AIM: To establish a threshold value for liver fat content between healthy children and those with non-alcoholic fatty liver disease (NAFLD) by using magnetic resonance imaging (MRI), with liver biopsy serving as a reference standard.
BEZZI, Mario, CATALANO, Carlo, CHIESA, CLAUDIO, DI MARTINO, MICHELE, DI MISCIO, ROSSELLA, PACIFICO, Lucia, SACCONI, BEATRICE   +6 more
core   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Association between non-high-density lipoprotein cholesterol and non-alcoholic fatty liver disease among people living with HIV on dolutegravir-based antiretroviral therapy: A cross-sectional study in Southwestern Uganda

BMC Research Notes
Objective Non-high-density lipoprotein cholesterol, an aggregate marker of atherogenic lipoproteins, has been implicated in metabolic dysfunction and may predict non-alcoholic fatty liver disease risk.
Charles Nkubi Bagenda, Carol Nantongo, Elastus Ssemwanga, Michael Junior Mugisa, Jesca Wafwoyo Akoth, Daniel Nzaramba, Rogers Kalyetsi, Elizabeth A. John, Jazira Tumusiime, Blendar Ainebyoona, Shadrach Omara, Vicent Mwesigye, Sylvia Achieng Lumumba, Conrad Lubwama, Benson Musinguzi, Lucas Ampaire, Rose Nassali, Herbert Itabangi, Lawrence Obado Osuwat, Brian Ssenkumba, Ronald Ouma Omolo   +20 more
doaj   +1 more source

Influence of Hyperhomocysteinemia on Development of Non-Alcoholic Fatty Liver Disease in Diabetes Mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
In 137 patients with diabetes mellitus, non-alcoholic fatty liver disease and with combination of these diseases there had been studied the pathogenetic mechanisms of hyperhomocysteinemia influence on formation of non-alcoholic fatty liver disease.
A.V. Vlasenko
doaj   +1 more source

Effect of Training Intensity on HIF-1a Gene Expression and Cardiac TG Content in Rats with Non-Alcoholic Fatty Liver Disease

, 2022
Mahdi Bagherian, Abdolali Banaeifar, Sajad Arshadi, Mohammad Ali Azarbayjani   +3 more
openalex   +1 more source

Association of adiponectin rs17300539 gene polymorphism with a non-alcoholic fatty liver disease in an Iranian population [PDF]

, 2018
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, resulting from exceeding fat cumulating in the liver .Adiponectin, a protein secreted from the adipose tissue, reduces liver inflammation.
Hedayati, Mehdi, Nezhadali, Masoumeh, Rezaei, Fahimeh   +2 more
core  

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Sex-specific effect of dietary fatty acids on non-alcoholic fatty liver disease

Frontiers in Nutrition
BackgroundNon-alcoholic fatty liver disease is the most common chronic hepatic disease worldwide. Dietary fatty acid is tightly associated with the development of non-alcoholic fatty liver disease but few large-scale and in-depth clinical researches have
Jianhua Chen, Zeqin Zhang, Yuning Pan, Jiejun Shi   +3 more
doaj   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source