Heterogeneity of non‐alcoholic fatty liver disease [PDF]
Liver International, 2015 See Article on Page ...
Yki‐Järvinen, Hannele +1 more
openaire +2 more sources
Precision Medicine in Fatty Liver Disease/Non-Alcoholic Fatty Liver Disease
Journal of Personalized Medicine, 2023 Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, and is related to fatal and non-fatal liver, metabolic, and cardiovascular complications. Its non-invasive diagnosis and effective treatment remain an unmet clinical need.
Laura Valenzuela-Vallejo +2 more
openaire +3 more sources
Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease? [PDF]
, 2019 Lysosomal acid lipase (LAL) plays a key role in intracellular lipid metabolism. Reduced LAL activity promotes increased multi-organ lysosomal cholesterol ester storage, as observed in two recessive autosomal genetic diseases, Wolman disease and ...
Angelico, F +7 more
core +1 more source
BMC Medicine, 2022 Background The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood.
Shanshan Wu +6 more
doaj +1 more source
Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. [PDF]
PLoS ONE, 2015 Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic ...
Agnieszka Zwolak +4 more
doaj +1 more source
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +1 more source
Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease. [PDF]
PLoS ONE, 2016 Although non-alcoholic and alcoholic fatty liver disease have been intensively studied, concerning pathophysiological mechanisms are still incompletely understood.
Vera H I Fengler +10 more
doaj +1 more source
Journal of Nepal Medical Association, 2021 Introduction: Non-alcoholic fatty liver disease is fatty infiltration of the liver in the absence of other causes of steatosis. It is strongly associated with central adiposity, high body mass index, insulin resistance states, hypertension ...
Bom BC +4 more
doaj +1 more source
[Non-alcoholic fatty liver disease (NAFLD)].
Recenti progressi in medicina, 2016 Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in adults and in the pediatric population of the western world; in a substantial proportion of subjects it takes on the characteristics of non-alcoholic steatohepatitis (NASH).
BUGIANESI, Elisabetta, MARIETTI, Milena
openaire +3 more sources
Similar reduction of cholesterol-adjusted Vitamin E serum levels in simple steatosis and non-alcoholic steatohepatitis [PDF]
, 2015 OBJECTIVES: Reduced vitamin E levels have been reported in patients with non-alcoholic steatohepatitis (NASH), but no conclusive data on patients with simple steatosis (SS) are available. Aim of this study was to investigate the association betweenserum
Angelico, Francesco +13 more
core +1 more source