Results 231 to 240 of about 10,125,713 (289)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Ponatinib alleviates non-alcoholic steatohepatitis through TFEB-mediated autophagy. [PDF]

Front Pharmacol
Lin Z, Yang M, Yu X, Tan G, Zhong J.
europepmc   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Potential diagnostic marker gene set for non-alcoholic steatohepatitis associated hepatocellular carcinoma with lymphocyte infiltration. [PDF]

Transl Cancer Res
Wang X, Gao M, Zhang Z, Ao X, Luo A, Wen Z, Pan X, Sun M, Wang T, Jia Z.   +9 more
europepmc   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

Aging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John‐Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, Giovanna Lollo, Rémi Mounier, Gaëtan Juban, Charalampos Rallis, David Carling, Filipe Cabreiro, Helena M. Cochemé   +15 more
wiley   +1 more source

Water-Soluble Cellulose Acetate Changes the Intestinal Microbiota in Mice with Non-Alcoholic Steatohepatitis. [PDF]

Nutrients
Iida A, Takahashi E, Kuranuki S, Shimamoto S, Nakamura T, Kitagaki H.   +5 more
europepmc   +1 more source

Meta‐Analysis: Enhanced Liver Fibrosis (ELF) Test for Identifying Significant Fibrosis, Advanced Fibrosis, and Cirrhosis in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 864-889, October 2026.
A metaanalysis of 34 studies/37 cohorts using the Siemens Healthineers ELF test for biopsy‐staged F2, F3, or F4 MASLD‐associated fibrosis validates 9.0 (≥F2), 9.8 (≥F3), and 11.3 (F4) cut‐offs, and establishes 10.5 as a high‐specificity F4 cut‐off. This potentially holds implications for guideline revisions and aiding qualification for antifibrotic ...
Matthew F. W. Gee, Donald B. Chalfin, Edward B. De Vol, H. Roma Levy, Artem T. Boltyenkov, Mario Gutierrez Casale, Arun J. Sanyal   +6 more
wiley   +1 more source

Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study. [PDF]

World J Gastroenterol
Xiong FX, Sun L, Zhang XJ, Chen JL, Zhou Y, Ji XM, Meng PP, Wu T, Wang XB, Hou YX.   +9 more
europepmc   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, Volume 183, Issue 19, Page 5935-5952, October 2026.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

Neutrophil extracellular traps-triggered hepatocellular senescence exacerbates lipotoxicity in non-alcoholic steatohepatitis. [PDF]

J Adv Res
Xu M, Xu H, Ling YW, Liu JJ, Song P, Fang ZQ, Yue ZS, Duan JL, He F, Wang L.   +9 more
europepmc   +1 more source