Results 221 to 230 of about 10,125,713 (289)

Chronic Liver Disease Self‐Management for Veterans: A Feasibility Trial

Lifestyle Medicine, Volume 7, Issue 4, October 2026.
ABSTRACT Background Rates of chronic liver disease (CLD) related to obesity and other cardiometabolic risk factors have increased dramatically and contribute to significant health burden and mortality. Lifestyle modification is commonly recommended, with a focus on nutrition, exercise, medication adherence, screening for CLD complications, and active ...
Carol Gonzalez, Ann Deioma, Heather M. Patton, Erik J. Groessl   +3 more
wiley   +1 more source

Correction: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model <i>in vivo</i>. [PDF]

Front Pharmacol
Li H, Xi Y, Xin X, Feng Q, Hu Y.
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Ethanol extract of Polygonatum cyrtonema Hua mitigates non-alcoholic steatohepatitis in mice. [PDF]

Front Pharmacol
Chen D, Shen Y, Huang F, Huang B, Xu S, Li L, Liu J, Li Z, Li X.   +8 more
europepmc   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Butein Alleviates Non-Alcoholic Steatohepatitis in Leptin-Deficient Mice by Modulating the PDE4/cAMP/p-CREB Pathway. [PDF]

Drug Des Devel Ther
Guo C, Zhang Y, Xue H, Zhao X, Wang B, Deng L, Zhu X, Zhang X, Zhang Y, Liu Y.   +9 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

European Bilberry Extract Ameliorates Dietary Advanced Glycation End Products-Induced Non-Alcoholic Steatohepatitis in Rats via Gut Microbiota and Its Metabolites. [PDF]

Nutrients
Shen L, Cheng R, Chen W, Liu H, Wang X, He R, Mo X, Liu L.   +7 more
europepmc   +1 more source

Inhibition of COX‐2‐Mediated Arachidonic Acid Metabolism by FGF21‐PPARα Axis Alleviates Liver Steatosis

MedComm, Volume 7, Issue 10, October 2026.
Under physiological conditions, the FGF21‐PPARα axis restrains COX‐2 and maintains arachidonic acid (AA) metabolic homeostasis. During steatotic liver disease, ERK1/2 phosphorylation increases alongside adaptive FGF21/PPARα activation, which is insufficient to suppress COX‐2, leading to COX‐driven AA remodeling, PGE2 accumulation, inflammation, and ...
Guangsen Xu, Tingting Pan, Guiyun Wang, Feng Qiu, Junlin Leng, Qiyang Feng, Yongguo Xue, Ye Wang, Junwei Zheng, Huiying Lu, Bingyan Han, Suntao Wang, Jie Du, Jiaojian Lv, Baile Wang, Xuebo Pan   +15 more
wiley   +1 more source

A New Hope for the Patients of Non-Alcoholic Steatohepatitis: FDA Gives Green Signal for Resmetirom Use. [PDF]

Health Sci Rep
Hasan AH, Abid MA, Abid MH, Suhail L, Nazir A.   +4 more
europepmc   +1 more source