Results 41 to 50 of about 145,187 (366)

Lipotoxicity as the Leading Cause of Non-Alcoholic Steatohepatitis

International Journal of Molecular Sciences, 2022
The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing factor for chronic liver complications, such as cirrhosis and/or development of ...
M. Branković, I. Jovanovic, Marija Dukić, T. Radonjić, S. Oprić, S. Klašnja, M. Zdravković   +6 more
semanticscholar   +1 more source

Extracellular vesicles in non-alcoholic and alcoholic fatty liver diseases

Liver Research, 2018
Fatty liver diseases, non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common causes of chronic liver diseases around the world.
Akiko Eguchi, Ariel E. Feldstein
doaj   +1 more source

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis

Gut, 2022
Objective Clinical diagnosis and approval of new medications for non-alcoholic steatohepatitis (NASH) require invasive liver biopsies. The aim of our study was to identify non-invasive biomarkers of NASH and/or liver fibrosis.
Giulia Angelini, S. Panunzi, L. Castagneto-Gissey, F. Pellicanò, A. De Gaetano, Maurizio Pompili, L. Riccardi, M. Garcovich, M. Raffaelli, L. Ciccoritti, O. Verrastro, Maria F. Russo, F. Vecchio, G. Casella, James R Casella-Mariolo, Luigi Papa, P. Marini, Francesco Rubino, C. L. le Roux, S. Bornstein, G. Mingrone   +20 more
semanticscholar   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Lifestyle modification in NAFLD/NASH: Facts and figures

JHEP Reports, 2019
Summary: The development of non-alcoholic fatty liver disease is closely linked to lifestyle factors, namely excessive caloric intake coupled with reduced physical activity and exercise. This review aims to examine the evidence behind lifestyle change as
Kate Hallsworth, Leon A. Adams
doaj   +1 more source

Metabolic preconditions for the formation and progression of steatohepatitis of alcoholic, mixed, non-alcoholic aetiology and their comorbidity with obesity and anaemic conditions

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. The urgency of the problem of comorbidity of alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) with anaemic conditions and the need for their differentiated correction is determined by the significant frequency of these
T. Antofiichuk, O. Khukhlina, M. Antofiichuk, N. Kaspruk   +3 more
doaj   +1 more source

Relationship between adipose tissue dysfunction, Vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease [PDF]

, 2017
Non-alcoholic fatty liver disease ( NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood.
BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CAROTTI, Simone, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, Morini, Sergio, VESPASIANI GENTILUCCI, UMBERTO   +7 more
core   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis

Arquivos de Gastroenterologia, 2011
CONTEXT: Non-alcoholic steatohepatitis is a disease with a high incidence, difficult diagnosis, and as yet no effective treatment. So, the use of experimental models for non-alcoholic steatohepatitis induction and the study of its routes of development ...
Éder Marcolin, Luiz Felipe Forgiarini, Juliana Tieppo, Alexandre Simões Dias, Luiz Antonio Rodrigues de Freitas, Norma Possa Marroni   +5 more
doaj   +1 more source

Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana, Angelico, Francesco, Baratta, Francesco, DEL BEN, Maria, Pastori, Daniele, Perri, Ludovica, Polimeni, Licia, Violi, Francesco   +7 more
core   +1 more source