Results 141 to 150 of about 8,104,442 (314)

Modelling and Evaluation of Lexical and Syntactic Alignment with a Priming-Based Microplanner

, 2010
Buschmeier H, Bergmann K, Kopp S. Modelling and Evaluation of Lexical and Syntactic Alignment with a Priming-Based Microplanner. In: Krahmer E, Theune M, eds. Empiricial Methods in Natural Language Generation. Lecture Notes in Computer Science. Vol 5790.
Kopp, Stefan ; https://orcid.org/, Theune, Mariët, Kirsten Bergmann, Bergmann, Kirsten, Stefan Kopp, Buschmeier, Hendrik ; https://orcid.org/, Krahmer, Emiel, Hendrik Buschmeier   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Cervical Alignment and Range of Motion Change after Anterior 3‐Level Hybrid Surgery Compared with Cervical Laminoplasty: A Matched Cohort Study

Orthopaedic Surgery
Objectives Cervical alignment and range of motion (ROM) changes after cervical spine surgery are related to cervical biomechanical and functions. Few studies compared these parameters between posterior laminoplasty and anterior 3‐level hybrid surgery ...
Yuxiao Deng, Junbo He, Hua Chen, Beiyu Wang, Quan Gong, Tao Li, Hao Liu   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Alignment of IT projects with business strategy: An analysis of the interrelationships between the factors affecting IS alignment at strategic, tactical and operational levels

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Despite numerous efforts to integrate business and IS strategic plans, organisations are not delivering the expected benefits from IS investment.
Gutiérrez Mendoza, Anabel Sara
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Gestural Alignment in Natural Dialogue

, 2012
Bergmann K, Kopp S. Gestural Alignment in Natural Dialogue. In: Cooper RP, Peebles D, Miyake N, eds. Proceedings of the 34th Annual Conference of the Cognitive Science Society (CogSci 2012).
Kopp, Stefan ; https://orcid.org/, Bergmann, Kirsten, Peebles, David, Cooper, Richard P., Miyake, Naomi   +4 more
core