Results 231 to 240 of about 12,851,211 (266)

PeptiVerse: A unified platform for therapeutic peptide property prediction. [PDF]

Nat Commun
Zhang Y, Tang S, Chen T, Mahood E, Vincoff S, Chatterjee P.   +5 more
europepmc   +1 more source

Age- and Sex-Specific Reference Intervals for Amino Acids and Acylcarnitines by Tandem Mass Spectrometry in a Kazakhstani Paediatric Population: An Indirect Data-Mining Study. [PDF]

Diagnostics (Basel)
Suleimenov Y, Assemov A, Rsaldina D, Baikatov A, Omarova A, Bespalko A.   +5 more
europepmc   +1 more source

Non-Canonical Amino Acids in Analyses of Protease Structure and Function

International Journal of Molecular Sciences, 2023
All known organisms encode 20 canonical amino acids by base triplets in the genetic code. The cellular translational machinery produces proteins consisting mainly of these amino acids. Several hundred natural amino acids serve important functions in metabolism, as scaffold molecules, and in signal transduction.
Nediljko Budisa, Peter Goettig, Nikolaj Georg Koch   +2 more
exaly   +3 more sources

Development of Multivalent Conjugates with a Single Non-Canonical Amino Acid

ChemBioChem, 2023
AbstractProteins represent powerful biomacromolecules due to their unique functionality and broad utility both in the cell and in non‐biological applications. The genetic encoding of non‐canonical amino acids (ncAAs) facilitates functional diversification of these already powerful proteins.
Douglas D. Young, Elizabeth King
exaly   +3 more sources

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Incorporation of non-canonical amino acids into proteins in yeast

Fungal Genetics and Biology, 2016
Non-canonical amino acids add extraordinary chemistries to proteins when they gain access to translation. In yeast, they can be incorporated into proteins by replacing a canonical amino acid or in a site-specific manner in response to an amber stop codon.
Birgit Wiltschi
exaly   +3 more sources

Enzymes with noncanonical amino acids

Current Opinion in Chemical Biology, 2020
Enzyme design and engineering strategies rely almost exclusively on nature's alphabet of twenty canonical amino acids. Recent years have seen the emergence of powerful genetic code expansion methods that allow hundreds of structurally diverse amino acids to be installed into proteins in a site-selective manner.
Zhao, Jingming, Burke, Ashleigh J., Green, Anthony P.   +2 more
openaire   +3 more sources

Incorporation of Non‐canonical Amino Acids into 2,5‐Diketopiperazines by Cyclodipeptide Synthases

Angewandte Chemie International Edition, 2018
AbstractThe manipulation of natural product biosynthetic pathways is a powerful means of expanding the chemical diversity of bioactive molecules. 2,5‐diketopiperazines (2,5‐DKPs) have been widely developed by medicinal chemists, but their biological production is yet to be exploited.
Nicolas Canu, Pascal Belin, Robert Thai, Isabelle Correia, Olivier Lequin, Jérôme Seguin, Mireille Moutiez, Muriel Gondry   +7 more
openaire   +3 more sources

Non‐Canonical Amino Acids in Protein Polymer Design

Polymer Reviews, 2007
Protein polymers can be prepared with essentially absolute control of chain length, sequence, and stereochemistry through biological synthesis in microbial hosts. But for the polymer chemist, the twenty “canonical” amino acids provide an unacceptably small set of starting materials for macromolecular design.
Connor, Rebecca E., Tirrell, David A.
openaire   +2 more sources