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The Role of Glycolysis in Tumorigenesis-The Many Unresolved Issues. [PDF]
CellsMarcucci F, Wei S, Cordani M.
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Non-canonical amino acids in protein engineering
Current Opinion in Biotechnology, 2003Methods for engineering proteins that contain non-canonical amino acids have advanced rapidly in the past few years. Novel amino acids can be introduced into recombinant proteins in either a residue-specific or site-specific fashion. The methods are complementary: residue-specific incorporation allows engineering of the overall physical and chemical ...
Link, A. James +2 more
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Enzymes with noncanonical amino acids
Current Opinion in Chemical Biology, 2020Enzyme design and engineering strategies rely almost exclusively on nature's alphabet of twenty canonical amino acids. Recent years have seen the emergence of powerful genetic code expansion methods that allow hundreds of structurally diverse amino acids to be installed into proteins in a site-selective manner.
Zhao, Jingming +2 more
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Non‐Canonical Amino Acids in Protein Polymer Design
Polymer Reviews, 2007Protein polymers can be prepared with essentially absolute control of chain length, sequence, and stereochemistry through biological synthesis in microbial hosts. But for the polymer chemist, the twenty “canonical” amino acids provide an unacceptably small set of starting materials for macromolecular design.
Connor, Rebecca E., Tirrell, David A.
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Incorporation of non-canonical amino acids into proteins in yeast
Fungal Genetics and Biology, 2016Non-canonical amino acids add extraordinary chemistries to proteins when they gain access to translation. In yeast, they can be incorporated into proteins by replacing a canonical amino acid or in a site-specific manner in response to an amber stop codon.
Wiltschi, Birgit
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Substitution enables significant new decay channels for a non-canonical amino acid
Physical Chemistry Chemical Physics, 2022In this paper, we have investigated the nonradiative processes of indole (Ind) and 7-fluoroindole (7F-Ind) using high-level theoretical and spectroscopic methods.
Paulami Ghosh +3 more
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Recent Advances in Fluorescence Imaging by Genetically Encoded Non-canonical Amino Acids
Journal of Molecular Biology, 2022Technical innovations in protein labeling with a fluorophore at the specific residue have played a significant role in studying protein dynamics. The genetic code expansion (GCE) strategy enabled the precise installation of fluorophores at the tailored site of proteins in live cells with minimal perturbation of native functions.
Sanghee Lee, Jonghoon Kim, Minseob Koh
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Synthesis of non-canonical amino acids through dehydrogenative tailoring
NatureAmino acids are essential building blocks in biology and chemistry. Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues1-3. The selective modification of amino acid side-chain residues represents an efficient strategy to access non-canonical derivatives of value in ...
Xin Gu +8 more
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Metal-chelating non-canonical amino acids in metalloprotein engineering and design
Current Opinion in Structural Biology, 2018The ability to rationally design metalloproteins with desired functions remains a difficult challenge despite many years of effort. Recently, the potential of using genetically encoded metal-chelating non-canonical amino acids (NCAAs) to circumvent longstanding difficulties in this field has begun to be explored.
Patrick J Almhjell, Jeremy H Mills
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PURE - Deliverable 2.1. Bioproduction of non-canonical amino acids
2022The non-canonical amino acid (ncAA) L-azidohomoalanine (Aha) is a methionine analog thatcan be introduced into proteins in E. coli instead of methionine by the supplementation of amethionine-auxotrophic strain [1]. The azido group in the side chain of Aha is reactive andselectively reacts with ligands carrying terminal alkynes in the presence of copper
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