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Synthesis of non-canonical amino acids through dehydrogenative tailoring
NatureAmino acids are essential building blocks in biology and chemistry. Whereas nature relies on a small number of amino acid structures, chemists desire access to a vast range of structurally diverse analogues1-3. The selective modification of amino acid side-chain residues represents an efficient strategy to access non-canonical derivatives of value in ...
Xin Gu +8 more
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Biosynthesis and biotechnological application of non-canonical amino acids: Complex and unclear
Biotechnology Advances, 2018Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions.
Mo Xian, Huibin Zou
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Recombinant hBMP4 incorporated with non-canonical amino acid for binding to hydroxyapatite
Biotechnology Letters, 2011A novel growth factor containing non-canonical amino acids was designed and synthesized to enhance the binding to hydroxyapatite (HA). The designed protein was human bone morphogenetic protein 4 (hBMP4) incorporating diphosporylated serines (pSpS) that was found in salivary protein statherin and was reported to be responsible for binding to HA ...
Makoto, Sakuragi +3 more
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Metal-chelating non-canonical amino acids in metalloprotein engineering and design
Current Opinion in Structural Biology, 2018The ability to rationally design metalloproteins with desired functions remains a difficult challenge despite many years of effort. Recently, the potential of using genetically encoded metal-chelating non-canonical amino acids (NCAAs) to circumvent longstanding difficulties in this field has begun to be explored.
Patrick J Almhjell, Jeremy H Mills
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Identifying Secreted Proteins by Non-canonical Amino Acid Tagging
2012© 2012 The Protein Society.
Mahdavi, Alborz +2 more
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Non-canonical amino acids as building blocks: new translation systems for non-canonical amino acids
2018openaire +1 more source