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Biosynthesis and biotechnological application of non-canonical amino acids: Complex and unclear
Biotechnology Advances, 2018Compared with the better-studied canonical amino acids, the distribution, metabolism and functions of natural non-canonical amino acids remain relatively obscure. Natural non-canonical amino acids have been mainly discovered in plants as secondary metabolites that perform diversified physiological functions.
Mo Xian, Huibin Zou
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Enzymes with noncanonical amino acids
Current Opinion in Chemical Biology, 2020Enzyme design and engineering strategies rely almost exclusively on nature's alphabet of twenty canonical amino acids. Recent years have seen the emergence of powerful genetic code expansion methods that allow hundreds of structurally diverse amino acids to be installed into proteins in a site-selective manner.
Zhao, Jingming +2 more
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Incorporation of Non-canonical Amino Acids into 2,5-Diketopiperazines by Cyclodipeptide Synthases
Angewandte Chemie - International Edition, 2018AbstractThe manipulation of natural product biosynthetic pathways is a powerful means of expanding the chemical diversity of bioactive molecules. 2,5‐diketopiperazines (2,5‐DKPs) have been widely developed by medicinal chemists, but their biological production is yet to be exploited.
Pascal Belin +2 more
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The Promising Role of Amine Transaminase Cascades in the Synthesis of Non-Canonical Amino Acids [PDF]
ProcessesAmine transaminases (ATA) are critical players in producing non-canonical amino acids, essential building blocks in pharmaceuticals and fine chemicals.
Najme Gord Noshahri, Jens Rudat
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Recombinant hBMP4 incorporated with non-canonical amino acid for binding to hydroxyapatite
Biotechnology Letters, 2011A novel growth factor containing non-canonical amino acids was designed and synthesized to enhance the binding to hydroxyapatite (HA). The designed protein was human bone morphogenetic protein 4 (hBMP4) incorporating diphosporylated serines (pSpS) that was found in salivary protein statherin and was reported to be responsible for binding to HA ...
Makoto, Sakuragi +3 more
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Metal-chelating non-canonical amino acids in metalloprotein engineering and design
Current Opinion in Structural Biology, 2018The ability to rationally design metalloproteins with desired functions remains a difficult challenge despite many years of effort. Recently, the potential of using genetically encoded metal-chelating non-canonical amino acids (NCAAs) to circumvent longstanding difficulties in this field has begun to be explored.
Patrick J Almhjell, Jeremy H Mills
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Identifying Secreted Proteins by Non-canonical Amino Acid Tagging
2012© 2012 The Protein Society.
Mahdavi, Alborz +2 more
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