Results 71 to 80 of about 210,904 (138)
Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid
eLife, 2017 TRPV1 channels support the detection of noxious and nociceptive input. Currently available functional and structural data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a ′bundle-crossing′ at the intracellular ...
Ximena Steinberg +9 more
doaj +1 more source
Human-specific transcriptional regulation of CNS development genes by FOXP2. [PDF]
, 2009 The signalling pathways controlling both the evolution and development of language in the human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is the only gene implicated in Mendelian forms of human speech and language ...
Bomar, Jamee M +9 more
core
A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]
, 2009 The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
core +1 more source
A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [PDF]
, 2002 Incorporation of non-natural amino acids into proteins in vivo expands the scope of protein synthesis and design. p-Acetylphenylalanine was incorporated into recombinant dihydrofolate reductase (DHFR) in Escherichia coli via a computationally designed ...
Carrico, Isaac S. +4 more
core +2 more sources
Frontiers in Molecular BiosciencesIntroductionPyrrolysyl-tRNA synthetase (PylRS) is a key enzyme for the site-specific incorporation of non-canonical amino acids (ncAAs) into proteins. However, its native form has a limited substrate scope.
Anastasia Dakhnevich +4 more
doaj +1 more source
Chimeric Translation for Mitochondrial Peptides: Regular and Expanded Codons
Computational and Structural Biotechnology Journal, 2019 Frameshifting protein translation occasionally results from insertion of amino acids at isolated mono- or dinucleotide-expanded codons by tRNAs with expanded anticodons.
Hervé Seligmann, Ganesh Warthi
doaj +1 more source
Beilstein Journal of Organic ChemistryFluorinated amino acids are essential building blocks in the spheres of protein engineering and medicinal chemistry. In the last decades, a large number of different synthetic strategies have been developed to produce a large variety of fluorinated amino
Maurizio Iannuzzi +5 more
doaj +1 more source
pH dependence of charge multipole moments in proteins
, 2017 Electrostatic interactions play a fundamental role in the structure and function of proteins. Due to ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge is not constant but varies with the changes in the ...
Bozic, Anze Losdorfer, Podgornik, Rudolf
core +1 more source
Frontiers in Pharmacology, 2019 The translation system is a sophisticated machinery that synthesizes proteins from 20 canonical amino acids. Recently, the repertoire of such composition has been expanded by the introduction of non-canonical amino acids (ncAAs) with the genetic code ...
Sumana Venkat +4 more
doaj +1 more source
Monitoring Replication Protein A (RPA) Dynamics in Homologous Recombination Through Site-specific Incorporation of Non-canonical Amino Acids [PDF]
, 2017 An essential coordinator of all DNA metabolic processes is Replication Protein A (RPA). RPA orchestrates these processes by binding to single-stranded DNA (ssDNA) and interacting with several other DNA binding proteins. Determining the real-time kinetics
Antony, Edwin +8 more
core +1 more source