Results 51 to 60 of about 11,400,092 (255)
Photoregulation of PRMT-1 Using a Photolabile Non-Canonical Amino Acid [PDF]
Molecules, 2021 Protein methyltransferases are vital to the epigenetic modification of gene expression. Thus, obtaining a better understanding of and control over the regulation of these crucial proteins has significant implications for the study and treatment of numerous diseases. One ideal mechanism of protein regulation is the specific installation of a photolabile-
Elizabeth A. King +8 more
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Incorporation of non-canonical amino acids into the developing murine proteome [PDF]
Scientific Reports, 2016 AbstractAnalysis of the developing proteome has been complicated by a lack of tools that can be easily employed to label and identify newly synthesized proteins within complex biological mixtures. Here, we demonstrate that the methionine analogs azidohomoalanine and homopropargylglycine can be globally incorporated into the proteome of mice through ...
Sarah Calve +3 more
openaire +2 more sources
Synthesis of proteins containing non-canonical amino acids [PDF]
, 2021 0 Abstract: Non-canonical amino acids allow the introduction of new chemical properties into proteins, which is useful both for studying proteins, and designing proteins.
Knetl, Adam
core
Combinatorial Fusion Rules to Describe Codon Assignment in the Standard Genetic Code
Life, 2020 We propose combinatorial fusion rules that describe the codon assignment in the standard genetic code simply and uniformly for all canonical amino acids. These rules become obvious if the origin of the standard genetic code is considered as a result of a
Alexander Nesterov-Mueller +2 more
doaj +1 more source
Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides
Cell Reports, 2020 Summary: The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival. During growth, bacteria remodel their PG, releasing fragments that are predominantly re-internalized and recycled.
Sara B. Hernández +3 more
doaj +1 more source
Convenient Genetic Encoding of Phenylalanine Derivatives through Their α-Keto Acid Precursors
Biomolecules, 2021 The activity and function of proteins can be improved by incorporation of non-canonical amino acids (ncAAs). To avoid the tedious synthesis of a large number of chiral phenylalanine derivatives, we synthesized the corresponding phenylpyruvic acid ...
Li Liu +8 more
doaj +1 more source
, 2022 Proteinogenic amino acids are natural nutrients ingested daily from standard foods. Commercially manufactured amino acids are added to a wide range of nutritional products, including dietary supplements and regular foods.
Arashida, Naoko +9 more
core +1 more source
Expanding Protein Sequence Space through Incorporation of Non-Canonical Amino Acids [PDF]
, 2013 Protein sequence space has been augmented by researchers wanting to expand the diversity of chemical functionalities that can exist within proteins. Artificial amino acids can range from simple atom substitutions such as fluorination, to installation of
Truong, Frank
core +1 more source
Aggregation characteristics of non-aromatic polar amino acids and its association to amyloids [PDF]
, 2023 Aggregation of amino acids to amyloid like structures is known to have implications in the pathophysiology of single amino acid based inborn-errors of metabolism (IEMs).
Neeraja , Revi +5 more
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In Vivo Incorporation of Multiple Unnatural Amino Acids [PDF]
, 2009 Unnatural amino acid (UAA) incorporation is an invaluable technique that is seeing increased use. THG73 is an amber suppressor tRNA used to incorporate > 100 residues at the UAG, amber stop codon, in Xenopus oocytes.
Rodriguez, Erik Ali
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