Results 91 to 100 of about 17,217,890 (291)

TRIM2 downregulation in clear cell renal cell carcinoma affects cell proliferation, migration, and invasion and predicts poor patients’ survival

, 2018
Wen Xiao, Xuegang Wang, Tao Wang, Jinchun Xing Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China Background and aim: Tripartite motif containing (TRIM) family protein has been involved in multiple ...
Xing J, Wang T, Xiao W, Wang X
core  

The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]

, 2008
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Roman A. Blaheta, Wedel, Steffen Alexander, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Steffen Wedel   +13 more
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DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Clear Cell Papillary Renal Cell Carcinoma – A New Emerging Entity [PDF]

, 2012
Clear cell papillary renal cell carcinoma was initially reported in patients with end stage renal disease under name of “end stage renal disease-associated renal cell carcinoma”.
Chen, MD, PhD, Frank, Sule, MD, PhD, Nobert, Xu, MD, PhD, Bo, Kanehira, MD, Kazunori, Sinnott, MD, Michael   +4 more
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Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Histology-specific Prognostic Impact of Microscopic Positive Surgical Margins in Renal Cell Carcinoma: Implications for Postoperative Surveillance

European Urology Open Science
Background and objective: Microscopic positive surgical margins (m-PSM) have been associated with adverse outcomes after surgery in renal cell carcinoma (RCC). However, their role in survival outcomes across RCC histologies remains unclear.
Giacomo Musso, Margaret F. Meagher, Mai Dabbas, Giuseppe Garofano, Natalie Birouty, Kit L. Yuen, Benjamin Baker, Cesare Saitta, Dattatraya Patil, Kazutaka Saito, Yosuke Yasuda, Hajime Tanaka, Francesco Montorsi, Alberto Briganti, Andrea Salonia, Umberto Capitanio, Alessandro Larcher, Giuseppe Rosiello, Yasuhisa Fujii, Viraj A. Master, Ithaar H. Derweesh   +20 more
doaj   +1 more source

Carbonic Anhydrase IX is Not a Predictor of Outcomes in Non-Metastatic Clear Cell Renal Cell Carcinoma - A Digital Analysis of Tissue Microarray

International Brazilian Journal of Urology, 2013
Introduction The knowledge about the molecular biology of clear cell renal cell carcinoma (ccRCC) is evolving, and Carbonic Anhydrase type IX (CA-IX) has emerged as a potential prognostic marker in this challenging disease.
Marcelo Zerati, Katia R. M. Leite, Jose Pontes-Junior, Cesar Camara Segre, Sabrina Thalita Reis, Miguel Srougi, Marcos Francisco Dall'oglio   +6 more
doaj   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Kidney renal clear cell carcinoma

, 2018
microRNA expression of Kidney renal clear cell carcinoma samples. Data from TGCA (https://cancergenome.nih.gov/
Filippo Geraci (5496950), Indrajit Saha (5497883)   +1 more
core   +1 more source

Glycosaminoglycan Profiling in Patients' Plasma and Urine Predicts the Occurrence of Metastatic Clear Cell Renal Cell Carcinoma. [PDF]

, 2016
Metabolic reprogramming is a hallmark of clear cell renal cell carcinoma (ccRCC) progression. Here, we used genome-scale metabolic modeling to elucidate metabolic reprogramming in 481 ccRCC samples and discovered strongly coordinated regulation of ...
Jens Nielsen, Maruzzo, M.,, Martin E. Johansson, Nilsson, Helén, Maruzzo, Marco, Stierner, U, Sven Lundstam, Volpi, N.,, Lundstam, Sven,, Maruzzo, M, Basso, U, VOLPI, Nicola, Roma, A, Umberto Basso, Roma, A.,, Nookaew, Intawat,, Helén Nilsson, Nielsen, Jens B.,, Nilsson, H.,, Gatto, Francesco, Volpi, N., Nielsen, Jens B,, Ulrika Stierner, Nielsen, Jens B., Nilsson, H., Nielsen, J., Nielsen, Jens B, Lundstam, S, Gatto, F, Nookaew, Intawat, Stierner, Ulrika,, Nilsson, H, Nicola Volpi, Johansson, Me, Nielsen, Jens, Maruzzo, M., Basso, U.,, Stierner, Ulrika, Roma, Anna, Francesco Gatto, Nookaew, I, Basso, Umberto, Basso, U., Roma, A., Johansson, M. E., Marco Maruzzo, Anna Roma, Gatto, Francesco,, Lundstam, Sven, Johansson, M. E.,, Intawat Nookaew, Nilsson, Helén,, Roma, Anna,, Maruzzo, Marco,, Nielsen, Jens,, Lund University., Volpi, Nicola,, Johansson, Martin E.,, Basso, Umberto,, Johansson, Martin E.   +59 more
core   +1 more source