Results 121 to 130 of about 17,217,890 (291)

A case of papillary renal cell carcinoma with para‐aortic lymph node metastasis that was completely resectable after treatment with combination therapy comprising lenvatinib and pembrolizumab and robot‐assisted radical nephrectomy

IJU Case Reports
Introduction Combination therapy comprising immune checkpoint inhibitors and molecular targeted therapies can be effective for metastatic non‐clear cell renal cell carcinoma.
Takayuki Hosoi, Shunsuke Yoshioka, Akari Hiraguri, Yusuke Kirihana, Tomoyuki Koguchi, Makoto Tamaki, Chiharu Irisawa   +6 more
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Advances in treatment strategies for non–clear cell renal cell carcinoma

Oncology and Translational Medicine
Abstract Renal cell carcinoma is the sixth most commonly diagnosed cancer in men and the tenth in women, with clear cell renal cell carcinoma accounting for nearly 75% of cases. The remaining 25% consists of non–clear cell renal cell carcinoma, a diverse and less prevalent group.
Shangwei Li, Liangyou Gu, Xin Ma, Xu Zhang   +3 more
openaire   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Sarcomatoid renal cell carcinoma

Saudi Journal of Kidney Diseases and Transplantation, 2011
Sarcomatoid renal cell carcinoma (SRCC) is an aggressive tumor variant thought to arise predominantly from differentiation of clear cell carcinoma. A few reports of SRCC asso-ciated with non-clear cell tumors led to the presumption that SRCC may arise ...
Kafil Akhtar, Ahmad Shamshad, Zaheer Sufian, Mansoor Tariq   +3 more
doaj  

Clear Cell Renal Cell Carcinoma 2022–2023

Clear cell renal cell carcinoma is a common tumor in Western countries and an appropriate test subject for new therapies. This Special Issue highlights the most up-to-date research into clear cell renal cell carcinoma from different medical perspectives,

core   +1 more source

A Case Report of Renal Cell Carcinoma Producing Alpha-Fetoprotein [PDF]

, 1992
We report a rare autopsy case of alpha-fetoprotein producing renal cell carcinoma with multiple metastases to liver, gallbladder, mesenterium, and paraaortic lymphnodes. A 58-year-old male patient was diagnosed as having carcinoma of the right kidney. On
Kiyuna, Masaya, Toda, Takayoshi, Shimajiri, Shouhei, Sasi, Ai Muktafi, Tamamoto, Tooru, Shingaki, Yoshisada, Hayakawa, Masamichi   +6 more
core  

Co-insidental, Ipsilateral Renal Cell Carcinoma and Urothelial Carcinoma of Ureter: A Rare Case

, 2016
Renal cell carcinoma and urothelial carcinoma of the upper urinary tract are not rare urological malignancies, however, in a patient with renal cell carcinoma and urothelial carcinoma seen simultaneously in the same kidney is a rare event.
Tarık Yonguç, Özgü Aydoğdu, Volkan Şen, İbrahim Halil Bozkurt, Tansu Değirmenci, İbrahim Küçüktürkmen, Bozkurt, İbrahim Halil, KÜÇÜKTÜRKMEN, İBRAHİM, YONGUÇ, TARIK, AYDOĞDU, ÖZGÜ, ŞEN, VOLKAN, DEĞİRMENCİ, TANSU   +11 more
core   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source