Results 71 to 80 of about 970,725 (346)

RNAcentral: a hub of information for non-coding RNA sequences

Nucleic Acids Res., 2018
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms.
B. Sweeney, Anton I. Petrov, Boris Burkov, R. Finn, A. Bateman, M. Szymanski, W. Karłowski, J. Gorodkin, S. Seemann, J. Cannone, Robin Gutell, P. Fey, S. Basu, Simon Kay, G. Cochrane, Kostantinos Billis, D. Emmert, Steven J. Marygold, R. Huntley, R. Lovering, A. Frankish, Patricia P. Chan, T. Lowe, E. Bruford, Ruth L. Seal, J. Vandesompele, P. Volders, M. Paraskevopoulou, Lina Ma, Zhang Zhang, S. Griffiths-Jones, J. Bujnicki, Pietro Boccaletto, J. Blake, C. Bult, Runsheng Chen, Yi Zhao, V. Wood, Kim M Rutherford, Elena Rivas, J. Cole, S. Laulederkind, M. Shimoyama, M. Gillespie, M. Orlic-Milacic, Ioanna Kalvari, Eric P. Nawrocki, S. Engel, J. Cherry, Silva Team, T. Berardini, A. Hatzigeorgiou, D. Karagkouni, K. Howe, Paul Davis, M. Dinger, Shunmin He, M. Yoshihama, N. Kenmochi, P. Stadler, K. Williams   +60 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review

Frontiers in Immunology
Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing promising results for numerous cancer patients.
Bibhu Prasad Satapathy, Pooja Sheoran, Rohit Yadav, Dewan Chettri, Dhruba Sonowal, Chinmayee Priyadarsini Dash, Prachi Dhaka, Vivek Uttam, Ritu Yadav, Manju Jain, Aklank Jain   +10 more
doaj   +1 more source

Alignment-free comparative genomic screen for structured RNAs using coarse-grained secondary structure dot plots

BMC Genomics, 2017
Background Structured non-coding RNAs play many different roles in the cells, but the annotation of these RNAs is lacking even within the human genome.
Yuki Kato, Jan Gorodkin, Jakob Hull Havgaard   +2 more
doaj   +1 more source

Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma

Frontiers in Immunology, 2023
IntroductionLow-grade glioma (LGG) is a prevalent malignant tumor in the intracranial region. Despite the advancements in treatment methods for this malignancy over the past decade, significant challenges still persist in the form of drug resistance and ...
Bo Shi, Bo Shi, Bo Shi, Fei Ge, Liangliang Cai, Liangliang Cai, Yi Yang, Yi Yang, Xiaohui Guo, Rui Wu, Zhehao Fan, Zhehao Fan, Binjie Cao, Binjie Cao, Ning Wang, Ning Wang, Yue Si, Yue Si, Xinyue Lin, Xinyue Lin, Weibing Dong, Haibo Sun, Haibo Sun   +22 more
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Non‐coding RNAs in cardiac hypertrophy [PDF]

The Journal of Physiology, 2017
AbstractHeart failure is one of the largest contributors to disease burden and healthcare outflow in the Western world. Despite significant progress in the treatment of heart failure, disease prognosis remains very poor, with the only curative therapy still being heart transplantation.
Lara Ottaviani, Paula A. da Costa Martins, Paula A. da Costa Martins   +2 more
openaire   +3 more sources

Epigenetic regulation in myocardial infarction: Non-coding RNAs and exosomal non-coding RNAs

Frontiers in Cardiovascular Medicine, 2022
Myocardial infarction (MI) is one of the leading causes of deaths globally. The early diagnosis of MI lowers the rate of subsequent complications and maximizes the benefits of cardiovascular interventions. Many efforts have been made to explore new therapeutic targets for MI, and the therapeutic potential of non-coding RNAs (ncRNAs) is one good example.
Sara Fadaei, Fatemeh Zarepour, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Amirhossein Sheida, Mohammad Shabani, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, Hamed Mirzaei   +13 more
openaire   +3 more sources

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review

Frontiers in Immunology
Recent advancements in genetic engineering have made it possible to modify Natural Killer (NK) cells to enhance their ability to fight against various cancers, including solid tumors.
Chinmayee Priyadarsini Dash, Dhruba Sonowal, Prachi Dhaka, Rohit Yadav, Dewan Chettri, Bibhu Prasad Satapathy, Pooja Sheoran, Vivek Uttam, Manju Jain, Aklank Jain   +9 more
doaj   +1 more source

Recent advances in the functional explorations of nuclear microRNAs

Frontiers in Immunology, 2023
Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs).
Xiaozhu Hu, Xiaozhu Hu, Guoquan Yin, Guoquan Yin, Yuan Zhang, Yuan Zhang, Liangyu Zhu, Liangyu Zhu, Haoyu Huang, Haoyu Huang, Kun Lv, Kun Lv   +11 more
doaj   +1 more source