Results 71 to 80 of about 963,524 (371)

Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions [PDF]

arXiv, 2022
Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With the rapid growth of sequencing technology, we have accumulated a massive amount of unannotated RNA sequences.
arxiv  

Recent advances in the functional explorations of nuclear microRNAs

Frontiers in Immunology, 2023
Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs).
Xiaozhu Hu, Xiaozhu Hu, Guoquan Yin, Guoquan Yin, Yuan Zhang, Yuan Zhang, Liangyu Zhu, Liangyu Zhu, Haoyu Huang, Haoyu Huang, Kun Lv, Kun Lv   +11 more
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

NON-CODING RNAs

, 2023
Since the introduction of the detailed structure of DNA by James Watson and Francis Crick in 1953, rapid developments have been made in the field of molecular biology over the past period. With the development of molecular biology techniques, detailed information about both coding and non-coding sequences of the genome has been obtained in whole genome
openaire   +2 more sources

Non-Coding RNAs and their Integrated Networks [PDF]

Journal of Integrative Bioinformatics, 2019
Abstract Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are different types of non-coding RNAs that modulate complex molecular and cellular processes. RNA sequencing technologies and bioinformatics methods greatly promoted the study of ncRNAs, which revealed ncRNAs’ essential roles in diverse aspects ...
Zhang, Peijing, Wu, Wenyi, Chen, Qi, Chen, Ming   +3 more
openaire   +6 more sources

Alignment-free comparative genomic screen for structured RNAs using coarse-grained secondary structure dot plots

BMC Genomics, 2017
Background Structured non-coding RNAs play many different roles in the cells, but the annotation of these RNAs is lacking even within the human genome.
Yuki Kato, Jan Gorodkin, Jakob Hull Havgaard   +2 more
doaj   +1 more source

B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cells

Frontiers in Immunology, 2023
Recent studies have demonstrated that a particular group of nucleated cells that exhibit erythroid markers (TER119 in mice and CD235a in humans) possess the ability to suppress the immune system and promote tumor growth.
Zhe Yang, Zhe Yang, Zheng Wang, Lei Wu, Lei Wu, Ying Wang, Ying Wang, Zhihui Xu, Ying Liu, Ying Liu, Fangfang Wang, Fangfang Wang, Duonan Yu, Duonan Yu   +13 more
doaj   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Long Non-Coding RNAs in the Cytoplasm

Genomics, Proteomics & Bioinformatics, 2016
Abstract An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human ...
Farooq Rashid, Abdullah Shah, Ge Shan
openaire   +4 more sources

Non-Coding RNAs in Endometrial Physiopathology [PDF]

International Journal of Molecular Sciences, 2018
The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their
La Ferlita, Alessandro, Battaglia, Rosalia, Andronico, Francesca, Caruso, Salvatore, Cianci, Antonio, Purrello, Michele, Di Pietro, Cinzia   +6 more
openaire   +3 more sources