Results 71 to 80 of about 558,269 (299)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review

Frontiers in Immunology
Recent advancements in genetic engineering have made it possible to modify Natural Killer (NK) cells to enhance their ability to fight against various cancers, including solid tumors.
Chinmayee Priyadarsini Dash, Dhruba Sonowal, Prachi Dhaka, Rohit Yadav, Dewan Chettri, Bibhu Prasad Satapathy, Pooja Sheoran, Vivek Uttam, Manju Jain, Aklank Jain   +9 more
doaj   +1 more source

Alignment-free comparative genomic screen for structured RNAs using coarse-grained secondary structure dot plots

BMC Genomics, 2017
Background Structured non-coding RNAs play many different roles in the cells, but the annotation of these RNAs is lacking even within the human genome.
Yuki Kato, Jan Gorodkin, Jakob Hull Havgaard   +2 more
doaj   +1 more source

Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma

Frontiers in Immunology, 2023
IntroductionLow-grade glioma (LGG) is a prevalent malignant tumor in the intracranial region. Despite the advancements in treatment methods for this malignancy over the past decade, significant challenges still persist in the form of drug resistance and ...
Bo Shi, Bo Shi, Bo Shi, Fei Ge, Liangliang Cai, Liangliang Cai, Yi Yang, Yi Yang, Xiaohui Guo, Rui Wu, Zhehao Fan, Zhehao Fan, Binjie Cao, Binjie Cao, Ning Wang, Ning Wang, Yue Si, Yue Si, Xinyue Lin, Xinyue Lin, Weibing Dong, Haibo Sun, Haibo Sun   +22 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Non‐coding RNAs in cardiac hypertrophy [PDF]

The Journal of Physiology, 2017
AbstractHeart failure is one of the largest contributors to disease burden and healthcare outflow in the Western world. Despite significant progress in the treatment of heart failure, disease prognosis remains very poor, with the only curative therapy still being heart transplantation.
Lara Ottaviani, Paula A. da Costa Martins, Paula A. da Costa Martins   +2 more
openaire   +3 more sources

Recent advances in the functional explorations of nuclear microRNAs

Frontiers in Immunology, 2023
Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in physiological and pathological activities, including microRNAs (miRNAs).
Xiaozhu Hu, Xiaozhu Hu, Guoquan Yin, Guoquan Yin, Yuan Zhang, Yuan Zhang, Liangyu Zhu, Liangyu Zhu, Haoyu Huang, Haoyu Huang, Kun Lv, Kun Lv   +11 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Shaping the Genome with Non-Coding RNAs [PDF]

Current Genomics, 2011
The human genome must be tightly packaged in order to fit inside the nucleus of a cell. Genome organization is functional rather than random, which allows for the proper execution of gene expression programs and other biological processes. Recently, three-dimensional chromatin organization has emerged as an important transcriptional control mechanism ...
Josée Dostie, Xue Qing David Wang, Jennifer Lynn Crutchley   +2 more
openaire   +4 more sources

B lymphocytes transdifferentiate into immunosuppressive erythroblast-like cells

Frontiers in Immunology, 2023
Recent studies have demonstrated that a particular group of nucleated cells that exhibit erythroid markers (TER119 in mice and CD235a in humans) possess the ability to suppress the immune system and promote tumor growth.
Zhe Yang, Zhe Yang, Zheng Wang, Lei Wu, Lei Wu, Ying Wang, Ying Wang, Zhihui Xu, Ying Liu, Ying Liu, Fangfang Wang, Fangfang Wang, Duonan Yu, Duonan Yu   +13 more
doaj   +1 more source