Results 81 to 90 of about 863,687 (283)

Non-coding RNA as lung disease biomarkers. [PDF]

, 2015
Biomarkers are quantifiable indicators of disease. These surrogates should be specific, sensitive, predictive, robust and easily accessible. A major class of RNA described as non-coding RNA fulfils many of these criteria, and recent studies have ...
Greene, Catherine M, McKiernan, Paul J, Vencken, Sebastian F   +2 more
core   +1 more source

Into the Wild: GWAS Exploration of Non-coding RNAs [PDF]

, 2018
Genome-wide association studies (GWAS) have proven a fundamental tool to identify common variants associated to complex traits, thus contributing to unveil the genetic components of human disease.
Giral, Hector, Kratzer, Adelheid, Landmesser, Ulf   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A genetic framework for RNAi inheritance in Caenorhabditis elegans

EMBO Reports
Gene regulation by RNA interference (RNAi) is a conserved process driven by double-stranded RNA (dsRNA). It responds to exogenous cues and drives endogenous gene regulation.
Jan Schreier, Lizaveta Pshanichnaya, Fridolin Kielisch, René F Ketting   +3 more
doaj   +1 more source

Alignment-free comparative genomic screen for structured RNAs using coarse-grained secondary structure dot plots

BMC Genomics, 2017
Background Structured non-coding RNAs play many different roles in the cells, but the annotation of these RNAs is lacking even within the human genome.
Yuki Kato, Jan Gorodkin, Jakob Hull Havgaard   +2 more
doaj   +1 more source

Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA [PDF]

, 2017
Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA).
Langer, Robert S, Martinez-Moreno, Margot, Ness, Jennifer K., O'Shea, Timothy Mark, Olaru, Alexander, Tapinos, Nikos, Zepecki, John P.   +6 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

New insights into neurodevelopmental disorders by whole genome sequencing of 100 families from Italy

npj Genomic Medicine
Neurodevelopmental disorders (NDDs) have a strong but largely unexplained genetic basis. Moreover, the genetic architecture of these complex disorders in under-represented communities is poorly studied.
Giovanni Spirito, Sara Trova, Gaia Treves, Khudayar Farmanli, Mariacristina Franzese Canonico, Agata Fant, Stefano Marangoni, Federica Furia, Debora Charrance, Nicola Locci, Sara Gottardo, Francesca Groppo, Vittoria Perseghin, Martina Toscano, Erika Bibbò, Serena Donetti Dontin, Cecilia Cargnelutti, Mélody Colliard, Alessandro Rosina, Anna Maria Beoni, Cristina Bérard, Alessandro Coppe, Paolo Serravalle, Fabio Landuzzi, Francesco Musacchia, Antonio Amoroso, Remo Sanges, Andrea Cavalli, Manuela Vecchi, Laure Obino, Stefano Gustincich   +30 more
doaj   +1 more source

RNA under Tension: Folding Landscapes, Kinetic Partitioning Mechanism, and Molecular Tensegrity

, 2012
Non-coding RNA sequences play a great role in controlling a number of cellular functions, thus raising the need to understand their complex conformational dynamics in quantitative detail.
Hyeon, Changbong, Lin, Jong-Chin, Thirumalai, D.   +2 more
core   +1 more source