Results 41 to 50 of about 729,139 (268)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Unsupervised Domain Adaptation using Graph Transduction Games

, 2019
Unsupervised domain adaptation (UDA) amounts to assigning class labels to the unlabeled instances of a dataset from a target domain, using labeled instances of a dataset from a related source domain.
Aslan, Sinem, Marchiori, Elena, Pelillo, Marcello, Torcinovich, Alessandro, van Laarhoven, Twan, Vascon, Sebastiano   +5 more
core   +1 more source

The skill of atmospheric linear inverse models in hindcasting the Madden–Julian Oscillation [PDF]

, 2014
A suite of statistical atmosphere-only linear inverse models of varying complexity are used to hindcast recent MJO events from the Year of Tropical Convection and the Cooperative Indian Ocean Experiment on Intraseasonal Variability/Dynamics of the Madden–
Allen, Teddy, Cavanaugh, Nicholas R., Mapes, Brian, Miller, Arthur J., Seo, Hyodae, Subramanian, Aneesh   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dynamical modeling and intelligent control of space soft manipulator

智能科学与技术学报, 2019
Space intelligent soft manipulator shows a broad prospect in the application of on-orbit service,due to its lightweight,dexterity and foldability.In this paper,a design of a modular soft manipulator with omnidirectional drivers was proposed.The dynamical
Xiang ZHANG, Hongwei LIU, Zhuoqun LIU, Zhenguo YAN, Xiaoqian CHEN, Yiyong HUANG   +5 more
doaj  

Orbital Behavior Intention Recognition for Space Non-Cooperative Targets Under Multiple Constraints

Aerospace
To address the issue of misclassification and diminished accuracy that is prevalent in existing intent recognition models for non-cooperative spacecraft due to the omission of environmental influences, this paper presents a novel recognition framework ...
Yuwen Chen, Xiang Zhang, Wenhe Liao, Guoning Wei, Shuhui Fan   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Improving Macrocell - Small Cell Coexistence through Adaptive Interference Draining

, 2012
The deployment of underlay small base stations (SBSs) is expected to significantly boost the spectrum efficiency and the coverage of next-generation cellular networks. However, the coexistence of SBSs underlaid to an existing macro-cellular network faces
Bennis, Mehdi, Debbah, Merouane, Latva-aho, Matti, Pantisano, Francesco, Saad, Walid   +4 more
core   +7 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source