Results 51 to 60 of about 11,450,544 (300)

Does Investor-State Dispute Settlement Discriminate Against Nationals?

open access: yesGerman Law Journal, 2020
This Article answers the question of whether investor-state dispute settlement (“ISDS”) discriminates against nationals by providing foreign investors with an extra avenue to challenge state measures. The complaint that ISDS is discriminatory as a matter
Christian Riffel
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Justifications for sex discrimination in employment : a comparative study of the law of the European Community, in the United Kingdom, the United States of America and the Federal Republic of Germany. [PDF]

open access: yes, 1992
The removal of discrimination between women and men in the workplace, in order to open up equality of opportunity in employment, is a measure of social policy regarded as desirable by makers of law and policy in Western liberal democracies, including ...
Hervey, Tamara K.
core   +5 more sources

Non-Discrimination

open access: yes
Non-discrimination is one of the most ubiquitous concepts in international economic law. It has been a central pillar of international trade law since well before GATT 1947, and is prominent across many WTO agreements, requiring WTO Members to accord the products and services of other Members treatment equivalent to that accorded to their domestic ...
Caroline Henckels   +2 more
  +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Data Anonymity Meets Non-discrimination [PDF]

open access: yes2013 IEEE 13th International Conference on Data Mining Workshops, 2013
We investigate the relation between t-closeness, a well-known model of data anonymization, and alpha-protection, a model of data discrimination. We show that t-closeness implies bd(t)-protection, for a bound function bd() depending on the discrimination measure at hand.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Tolerance and Non-Discrimination

open access: yesACROSS
Respect for tolerance and non-discrimination in press materials represent two fundamental legal and ethical obligations of the journalist from the Republic of Moldova.
Vladimir GÎRA, Ionel Constantin MITEA
doaj   +2 more sources

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