Results 61 to 70 of about 2,288,928 (273)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Online drawings for dementia diagnose: in-air and pressure information analysis [PDF]

, 2014
In this paper we present experimental results comparing on-line drawings for control population (left and right hand) as well as Alzheimer disease patients.
Faundez-Zanuy, Marcos, Garré Olmo, Josep, Lopez-de-Ipiña, Karmele, Roure Alcobé, Josep, Sesa Nogueras, Enric, Solé-Casals, Jordi   +5 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analyzing Grip Strength Disparities Between Dominant and Non-Dominant Hands: Influence of Sex and Age in the Polish Population

Applied Sciences
Handgrip strength (HGS) is a key indicator of muscular fitness and physical health. Recently, attention has focused on HGS asymmetry as a potential marker of functional impairment.
Hanna Zadoń, Katarzyna Nowakowska-Lipiec, Maria Filipek, Irmina Lepiarczyk, Aleksandra Matusiak, Anna Piechnik, Wojciech Pieniążek, Zofia Piejak, Martyna Przybylska, Maria Zadoń, Piotr Szaflik   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Coherent phenomena in semiconductors

, 1997
A review of coherent phenomena in photoexcited semiconductors is presented. In particular, two classes of phenomena are considered: On the one hand the role played by optically-induced phase coherence in the ultrafast spectroscopy of semiconductors; On ...
, Allen L, Bastard G, Bloch F, Cingolani R, Demtroeder W, Fausto Rossi, Fork R L, Goodnick S M, Haug H, Henneberger F, Jacoboni C, Kane M G, Kash J A, Kittel C, Koch S W, Kuhn T, Kuhn T, Levenson M D, Meystre P, Mills D L, Molinari E, Phillips R T, Rossi F, Rossi F, Rossi F, Rossi F, Rossi F, Rossi F, Rossi F, Sargent M III, Shah J, Shen Y R, Zener C   +33 more
core   +1 more source

Ethnic identity and aspirations among rural Alaska youth [PDF]

, 1998
The villages of rural Alaska comprise one of the most exceptional, yet least visible, sociocultural environments in the United States They are geographically remote, and set off from the mainstream also by their unique Eskimo, Indian or Aleut cultures ...
Duncan, Cynthia M., Grimes, Jody, Hamilton, Lawrence C., Seyfrit, Carole L.   +3 more
core   +2 more sources

Evaluation of Dominant and Non-Dominant Hand Movements For Volleyball Action Modelling [PDF]

Adjunct of the 2019 International Conference on Multimodal Interaction, 2019
In this paper, we assess the use of Inertial Measurement Units (IMU) in recognising different volleyball-specific actions. Analysis of the results suggests that all sensors in the IMU (i.e. magnetometer, accelerometer, barometer and gyroscope) contribute unique information in the classification of volleyball-specific actions.
Haider, Fasih, Salim, Fahim, Naghashi, Vahid, Tasdemir, Sena Busra Yengec, Tengiz, Izem, Cengiz, Kubra, Postma, Dees, Delden, Robby van, Reidsma, Dennis, van Beijnum, Bert-Jan, Luz, Saturnino   +10 more
openaire   +5 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source