Results 141 to 150 of about 1,219,806 (299)

Organic Fodder Production in Intensive Organic Livestock Production in Europe: Recent Scientific Findings and the Impact on the Development of Organic Farming [PDF]

, 2005
Organic farming is practiced in over 100 countries on more than 26 million hectares. In the European Union (EU 25), about 5.6 million hectares of farm land are certified under the EU organic farming regulation 2092/91/EEC.
Böhm, Herwart, Rahmann, Gerold
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Validation of the HEN model for organic laying hens and assessment of nutrition in organic poultry (CTE0202) [PDF]

, 2005
Introduction Regulation EC1804/1999 sets out the minimum standards for organic livestock production and UK organic poultry producers have to adhere to for organic poultry.
Gordon, S
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Prospects for the use of the aboveground biomass of southern cane (Phragmites australis (Cav.) Trin. ex. Steud.) in feed production technologies

Аграрная наука Евро-Северо-Востока
To increase the efficiency of feed production in Russian regions where there is a shortage of atmospheric soil moisture and unstable weather conditions, it is necessary to develop a set of measures to obtain highly nutritious feeds based on the rational ...
Svetlana A. Davydova, Aleksey I. Ryadnov, Anastasia O. Tishaninova, Tatiana V. Ananeva   +3 more
doaj   +1 more source

Oral Branched-Chain Amino Acid Supplements That Reduce Brain Serotonin During Exercise in Rats Also Lower Brain Catecholamines [PDF]

, 2013
Exercise raises brain serotonin release and is postulated to cause fatigue in athletes; ingestion of branched-chain amino acids (BCAA), by competitively inhibiting tryptophan transport into brain, lowers brain tryptophan uptake and serotonin synthesis ...
Choi, Sujean, DiSilvio, Briana, Fernstrom, John D., Fernstrom, Madelyn H.   +3 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Plasma Amino Acid Levels in Obese Adolescents: A Case-Control Study and the Review of the Literature

The Journal of Pediatric Academy
Optimal balance among amino acids in the circulation is important for body homeostasis. This study aims to evaluate and define the amino acids associated with obesity and insulin resistance.
Pembe Soylu Üstkoyuncu, Durmuş Doğan, Fatih Kardaş, Mustafa Kendirci, Mehmet Akif Dündar, Arife Canpolat, Yasemin Altuner   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source