Results 71 to 80 of about 834,502 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Materials Make a Better Life: Functional Metals, Metal Oxides, and Metal Complexes

, 2023
Materials based on metals, metal oxides, and metal complexes play an essential role in various areas of our lives [...
Aleksandra Radtke, Piotr Piszczek
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

EXAMINATION OF MACRO AND MICRO ELEMENTS IN PSETTA MAKSIMA AND SOLEA VULGARIS FROM THE BLACK AND NORTH EASTERN MEDITERRANEAN SEAS

Studia Universitatis Babes-Bolyai Chemia, 2019
The objective of this study was to determine the levels of essential (Ca, K, Na, Mg, Co, Cu, Cr, Fe, Mn) and non-essential (Al, As, Ba, Cd, Ni, Pb, Sr, Li, B) elements in the muscle, liver and skin of P. maxima and S. vulgaris.
Mustafa Kemal SANGUN, Cemal TURAN, Beyza ERSOY ALTUN   +2 more
doaj   +1 more source

Concentration levels of metals in commercially available Ethiopian roasted coffee powders and their infusions

Bulletin of the Chemical Society of Ethiopia, 2011
The concentrations of nine essential metals (K, Mg, Ca, Na, Mn, Fe, Cu, Zn, Co) and two non-essential (Pb, Cd) metals were determined in three brands of commercially available roasted Ethiopian coffee powders (Abyssinia, Alem and Pride) obtained from ...
Bhagwan Singh Chandravanshi, Ramato Ashu
doaj  

Associations between environmental non-essential heavy metals, ecobiochemistry and health [PDF]

, 2019
Environmental heavy metals should be a concern of the entire world due to its impact on the animal and human population. "Heavy metals" is a generic name used for metals characterized by relatively high atomic weight, density, and atomic number.
Ahmadi Mirela, Ştef Lavinia, Şmuleac Adrian, Milovanov Cornelia, Pascalau Raul, Dumitrescu Gabi, Mederle Narcisa, Smuleac Laura Iosefina, Nicula Marioara, Dronca Dorel, Pet Ioan   +10 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source