Results 51 to 60 of about 13,141,647 (272)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ferro-metals processing can be hazardous to your health [PDF]

Ferro-metals (or Ferro-alloys) are used in making steel, to add different characteristics to the steel. The ferro-metals are often in the form of rocks. The ferro-metals are produced by heating the ore of the needed additive with iron ore.
Ferro-metals
core   +2 more sources

Impact of Aspiculuris tetraptera infection on metal homeostasis in Mus musculus [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Heavy metals are persistent contaminants that disrupt metabolic, enzymatic, and immune functions in exposed organisms. However, how intestinal parasites influence host metal homeostasis-particularly through sequestration of trace elements-remains ...
M. Albeshr, R. Abdel-Gaber, S. Al Quraishy, E. M. Al-Shaebi   +3 more
doaj   +2 more sources

Levels of essential and non-essential metals in edible mushrooms cultivated in Haramaya, Ethiopia [PDF]

International Journal of Food Contamination, 2016
Fruiting bodies of two oyster mushroom (Pleurotus ostreatus and Pleurotus florida) species and their respective substrate samples cultivated and collected from the Mushroom Research, Production and Training Laboratory of the Haramaya University, Ethiopia, were analyzed for essential and non-essential metals, viz., Cu, Fe, Zn, Mn, Cd and Pb contents by ...
Gebrelibanos, Medhanye, Megersa, Negussie, Taddesse, Abi M.   +2 more
openaire   +1 more source

Essential and Non-Essential Metal Concentrations in Shrimps from Iskenderun Bay, Türkiye

Harran Üniversitesi Veteriner Fakültesi Dergisi, 2022
Contamination of the aquatic environment and living things with pollutants is increasing daily. Among these pollutants, heavy metals come to the forefront regarding toxicological and public health due to their widespread use, toxicity, and resistance to degradation, as well as accumulation and biomagnification in the food chain.
Mustafa Yipel, İbrahim Ozan Tekeli
openaire   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Toxicological interactions of silver nanoparticles and non-essential metals in human hepatocarcinoma cell line

Toxicology in Vitro, 2017
Toxicological interaction represents a challenge to toxicology, particularly for novel contaminants. There are no data whether silver nanoparticles (AgNPs), present in a wide variety of products, can interact and modulate the toxicity of ubiquitous contaminants, such as nonessential metals.
Miranda, Renata Rank, Bezerra Jr, Arandi Ginane, Oliveira Ribeiro, Ciro Alberto, Randi, Marco Antônio Ferreira, Voigt, Carmen Lúcia, Skytte, Lilian, Rasmussen, Kaare Lund, Kjeldsen, Frank, Filipak Neto, Francisco   +8 more
openaire   +3 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source