Results 41 to 50 of about 30,049 (242)

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Molecular Metabolism, 2022
Objective: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice.
Katrine D. Galsgaard, Emilie Elmelund, Christian D. Johansen, Anna B. Bomholt, Hüsün S. Kizilkaya, Frederik Ceutz, Jenna E. Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Mette M. Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J. Holst, Nicolai J. Wewer Albrechtsen   +16 more
doaj   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Lack of relationship between cord serum angiopoietin-like protein 4 (ANGPTL4) and lipolytic activity in human neonates born by spontaneous delivery.

PLoS ONE, 2013
BackgroundLigands of peroxisome-proliferator activated receptors (PPARs), such as non-esterified fatty acids (NEFAs), induce expression of angiopoietin-like protein 4 (ANGPTL4). Recently ANGPTL4 has been reported to be a mediator of intracellular adipose
Henar Ortega-Senovilla, Ute Schaefer-Graf, Katrin Meitzner, Kristof Graf, Michael Abou-Dakn, Emilio Herrera   +5 more
doaj   +1 more source

Non-esterified fatty acid metabolism and postprandial lipaemia

Atherosclerosis, 1998
Non-esterified fatty acids (NEFA, or free fatty acids) are an important metabolic fuel. Both the concentration of NEFA and their flux through the circulation vary widely from hour to hour, reflecting nutritional state and physical activity. Inappropriately elevated plasma NEFA concentrations may have a number of adverse effects on both carbohydrate and
openaire   +3 more sources

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy

Advanced Healthcare Materials, EarlyView.
This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe   +8 more
wiley   +1 more source

Internal lipids of sheep wool when a water-soluble complex of fatty acids is included into their diet

Біологічні студії
Background. An effective way to increase the productivity of sheep is through the use of fats in their feeding. With this in mind, the effect of a water-soluble complex of fatty acids on the internal lipids of wool sheep has been studied.
Vitalii Tkachuk, Bogdan Kyryliv, Nataliia Ohorodnyk, Nataliia Motko   +3 more
doaj   +1 more source

Effect of Intravenous Amino Acids on Plasma Non-Esterified Fatty Acids.

Experimental Biology and Medicine, 1959
Summary(1) The effect of infusing an amino acid mixture (protein hydrolysate) on plasma NEFA, venous glucose level, and capillary-venous glucose difference, was studied in 6 healthy volunteer subjects. In every instance, plasma NEFA levels fell precipitously during amino acid infusion, and capillary-venous glucose differences increased concurrently ...
S A, HASHIM, T B, VAN ITALLIE
openaire   +2 more sources

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Intensity of transition of heavy metals and content of non-esterified forms of fatty acids in newly constructed bee combs

Біологічні студії
Background. There is a debate in the literature about the presence of heavy metals, including toxic ones, in freshly built bee combs (tongues). At the same time, heavy metals in the wax-synthesizing glands of bees are involved in the synthesis of various
Yosyp Rіvіs, Volodymyr Pоstоienkо, Оlha Hоpаnеnkо, Ulyana Fedorovych, Daniel Zaborski, Оlha Stаdnytskа, Іvan Sаrаnchuk, Оleh Klym, Аndrii Shеlеvаch, Оleksandr Diachеnkо, Olena Bezaltychna   +10 more
doaj   +1 more source