Results 101 to 110 of about 12,845,141 (320)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Euclidean decompositions of hyperbolic manifolds and their duals [PDF]

, 2007
Epstein and Penner constructed in [EP88] the Euclidean decomposition of a non-compact hyperbolic n-manifold of finite volume for a choice of cusps, n >= 2. The manifold is cut along geodesic hyperplanes into hyperbolic ideal convex polyhedra.
Lukac, Sascha Georg
core  

An Unbiased Geometry‐Resolved Membrane Platform for Proteome‐Scale Discovery of Membrane Curvature Sensors

Advanced Science, EarlyView.
A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa, Rikuto Kawakami, Kunanon Chattrairat, Tatsuya Niwa, Taiga Ajiri, Takao Yasui, Masayoshi Tanaka   +6 more
wiley   +1 more source

La aplicación física de la geometría astral como confirmación de la teoría kantiana del conocimiento

Logos, 2007
The appearance of the non-Euclidean or astral geometries seemed to contradict the philosophy of the Kant´s mathematics. He had considered the possibility of a supreme geometry, but he discarded it due to it was not synthetically related with the ...
Juan Cano de Pablo
doaj  

The discovery of non-Euclidean geometry [PDF]

, 2014
This project gives a basic understanding of the difference between the Euclidean geometry and the non-Euclidean geometries (elliptic and hyperbolic). Furthermore the focus of the project is to describe the discovery of non-Euclidean geometry in the view ...
Salnaja, Alma, Rho, Aran
core  

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

One-loop quantization of Euclidean D3-branes in holographic backgrounds

Journal of High Energy Physics
In this note we analyze the semi-classical quantization of D3-branes in three different holographic backgrounds in type IIB string theory. The first background is Euclidean AdS5 with S 1 × S 3 boundary accompanied with a twist to preserve supersymmetry ...
Friðrik Freyr Gautason, Jesse van Muiden   +1 more
doaj   +1 more source

Cross-subject EEG emotion recognition using Riemannian Graph Transformers with Geodesic Adversarial Adaptation

Alexandria Engineering Journal
Cross-subject electroencephalography (EEG) emotion recognition poses a fundamental challenge for brain-computer interfaces due to two factors: the non-Euclidean geometry of EEG spatial covariance matrices and the substantial inter-subject variability in ...
Yun Gao, Hai Deng
doaj   +1 more source

Computing the nearest euclidean distance matrix with low embedding dimensions [PDF]

, 2013
Euclidean distance embedding appears in many high-profile applications including wireless sensor network localization, where not all pairwise distances among sensors are known or accurate.
Qi, Hou-Duo, Yuan, Xiaoming, Qi, Hou Duo
core   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source