Results 51 to 60 of about 793,373 (260)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Role of Accountability as a Mediating Variable of Accounting Information System Quality on Financial and Non-Financial [PDF]

open access: yesSHS Web of Conferences
This research aims to examine and obtain empirical evidence of the influence of the quality of accounting information systems on financial and non-financial performance in village government Wonosobo Regency.
Tahar Afrizal, Oktiyani Yona
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Metamorphosis of Risks of Material Misstatement in Statutory Audit, from Identification to Canon, in the Context of Globalization [PDF]

open access: yesAudit Financiar
In a context marked by the intensification of concerns for sustainable practices and transparency in corporate communication, the analysis of the factors influencing companies' decision to publish sustainability reports becomes relevant.
Oana V. TIRDEA (PREDOAIA)   +1 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

An in-Depth Investigation into the Impact That Awards and Recognition Have on the Performance of Staff Members

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
This study aims to examine the relationship between employee awards and performance. This investigation made use of publicly available information in its design, technique, and approach.
Burhaini Burhaini   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

PENGARUH KOMPENSASI FINANSIAL DAN KOMPENSASI-NON FINANSIAL TERHADAP KNERJA KARYAWAN DI RS MUHAMADIYAH BABAT

open access: yesMedia Mahardhika: Media Komunikasi Ekonomi dan Manajemen
This study aims to analyze the effect of financial and non-financial compensation on employee performance at Muhammadiyah Babat Hospital. Employee performance is a key factor in ensuring quality health services and patient satisfaction. This study uses a
Darianto Darianto   +4 more
doaj   +1 more source

Analysis of Financial and Non-Financial Performance of Marine Capture Fisheries Using Gillnet in Pulau Baai Port of Bengkulu Province

open access: yesIndonesian Journal of Agricultural Research, 2018
This study is aimed at analyzing the financial and non-financial performance of marine capture fisheries business in Baai Island Port. Stratified random sampling including 60 fishermen using gillnet fishing gear in Baai Island Port was used in this ...
Yohana Tambunan   +2 more
doaj   +1 more source

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