Results 91 to 100 of about 22,410,258 (325)

Primordial non-gaussianity from the bispectrum of 21-cm fluctuations in the dark ages [PDF]

, 2015
A measurement of primordial non-gaussianity will be of paramount importance to distinguish between different models of inflation. Cosmic microwave background (CMB) anisotropy observations have set unprecedented bounds on the non-gaussianity parameter ...
Julian B. Muñoz, Y. Ali-Haïmoud, M. Kamionkowski   +2 more
semanticscholar   +1 more source

Anomalous dimensions and non-gaussianity [PDF]

Journal of High Energy Physics, 2013
AbstractWe analyze the signatures of inflationary models that are coupled to interacting field theories, a basic class of multifield models also motivated by their role in providing dynamically small scales. Near the squeezed limit of the bispectrum, we find a simple scaling behavior determined by operator dimensions, which are constrained by the ...
Green, Daniel, Lewandowski, Matthew, Senatore, Leonardo, Silverstein, Eva, Zaldarriaga, Matias   +4 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Primordial non-Gaussianity in noncanonical warm inflation with nonminimal derivative coupling

European Physical Journal C: Particles and Fields
In this paper, the scenario of noncanonical warm inflation with nonminimal derivative coupling is introduced, and its primordial non-Gaussianity of perturbations on uniform energy density hypersurfaces is systematically analyzed.
Xiao-Min Zhang, Run-Qing Zhao, Yun-Cai Feng, Peng-Cheng Chu, Zhi-Peng Peng, Xi-Bin Li   +5 more
doaj   +1 more source

Emergent anomalous transport and non-Gaussianity in a simple mobile–immobile model: the role of advection

New Journal of Physics, 2023
We analyse the transport of diffusive particles that switch between mobile and immobile states with finite rates. We focus on the effect of advection on the density functions and mean squared displacements (MSDs).
Timo J Doerries, Ralf Metzler, Aleksei V Chechkin   +2 more
doaj   +1 more source

Signatures of non-gaussianity in the isocurvature modes of primordial black hole dark matter [PDF]

, 2015
Primordial black holes (PBHs) are black holes which may have formed very early on during the radiation dominated era in the early universe. We present here a method by which the large scale perturbations in the density of primordial black holes may be ...
S. Young, C. Byrnes
semanticscholar   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Primordial Non-Gaussianity in the Cosmic Microwave Background

Advances in Astronomy, 2010
In the last few decades, advances in observational cosmology have given us a standard model of cosmology. We know the content of the universe to within a few percent.
Amit P. S. Yadav, Benjamin D. Wandelt
doaj   +1 more source

Effective theory of large-scale structure with primordial non-Gaussianity [PDF]

, 2015
We develop the effective theory of large-scale structure for non-Gaussian initial conditions. The effective stress tensor in the dark matter equations of motion contains new operators, which originate from the squeezed limit of the primordial bispectrum.
Valentin Assassi, D. Baumann, E. Pajer, Y. Welling, D. van der Woude   +4 more
semanticscholar   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source